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Terra Sigillata

musings on medicines from the Earth

Profile

Small profile avatar.jpg Abel Pharmboy is the nom de plume of David J Kroll, a US state university educator and cancer researcher who holds a PhD in Pharmacology and Therapeutics and BS in Toxicology. He writes on natural product drugs and dietary supplements, issues of under-represented groups in the STEMM disciplines, science and medical journalism, the science and culture of North Carolina, Florida, and Colorado, making and listening to music and, with the help of his colleague, Erleichda, wine appreciation.

"Why Terra Sigillata?" will tell you more about the origin of the blog name.

Please read the DISCLAIMER for details on the blog's intended audience, advertising and comment policy, and how not to use the information presented herein.

For the record, this is a personal blog and any content or opinions expressed are solely the author's and do not reflect those of his university employer or funding agencies. He does get a bit ornery from time to time.

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Pharmacology:

My voice has been absent from the blogosphere. . .

Category: LungMutiny2010

Another gift of LungMutiny2010 has been the temporary loss of my voice secondary to inhaled corticosteroids.

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Sir James Black (1924-2010) - Physician, Pharmacologist, Gentleman

Category: Chemistry

It is rare for a scientist to discover one drug that makes it to market. Sir James not only led the discovery of two major drugs, propranolol and cimetidine. As if that were not enough, each drug was a "first-in-class" agent, the first approved drug that acts via a novel mechanism of action.

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Former date rape drug reincarnated as answer to unmet medical needs

Category: Chronic Illness

Another public health benefit of studying drugs of abuse. You just never know where new drugs will come from.

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Icariin from horny goat weed is structurally unrelated to sildenafil (Viagra®)

Category: Botanical/Herbal Medicines

A follow-on discussion of Pfizer's rejected patent claim and some molecular modeling thanks to valued readers, daedalus4u and Prof Ian Musgrave, respectively. You know, science blogging is cool.

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Horny Goat Weed (Epimedium spp.) is a limp excuse for Viagra, Cialis

Category: Pharmaceutical Law

Horny goat weed is far from stiff competition for a prescription PDE5 inhibitor like sildenafil (Viagra).

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Are testosterone-deficient men responsible for shortages of a life-saving drug for women with breast cancer?

Category: Cancer

A physician's claim that "between 100 and 1,000 times more men than women" are on the aromatase inhibitor anastrozole raises questions behind a worldwide shortage of the drug. Are testosterone-deficient men in effect killing women with breast cancer?

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Did the patient fail the treatment or did we fail the patient?

Category: Biotechnology

Referring to clinical drug resistance or refractoriness to therapy as "the patient failed the treatment" is pissing me off this morning before I have my coffee.

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James Ray's Sedona sweat lodge stash: lessons in polypharmacy and endocrine pharmacology

Category: The American Southwest

The suitcase full of supplements and prescription drugs seized in the execution of a search warrant for James Arthur Ray's Arizona retreat hotel room provides a learning opportunity in endocrine pharmacology and drug prescribing for off-label uses.

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Sir John Crofton, TB combination therapy pioneer - a long and admirable life

Category: Infectious diseases

Denise Gellene in the New York Times is reporting this morning that Scottish physician, Sir John Crofton, passed away on 3 November at age 97. Crofton is best known for implementing a combination drug regimen to treat tuberculosis, the insidious...

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Lashing out at Latisse®

Category: Advertising

I never knew that Brooke Shields suffered from hypotrichosis.

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