If you spend a lot of time peering into a window that opens into the World Wide Web, you may like using Verdana font set at a comfortable font size. I personally have set Firefox to ignore all site specific fonts and just use Verdana size 18 for all western fonts.
I’ve heard that Verdana is a poor choice as a web font for various reasons. I am not an expert on that but I know what I see and I see Verdana working well. My screen resolution is 1400 x 1050, the system is Microsoft Windows with ClearType installed.
If you run Windows, install ClearType. It’s one of the genuinely good things to come out of the evil empire.