Transcription and Translation

Archives for September, 2006

Credentials vs. Note Taking

A lesson of what not-to-do from Joseph Schlessinger (the “signaling guy” and head of Pharmacology at Yale) at the Yeda vs. ImClone Patent trial. Yeda provided detailed records of their development of Erbitux, ImClone provided no records, only Joseph Schlessinger’s account of a twenty year old conversation. The court stated: We find Schlessinger’s account of…

Map that Campus XVII

An easy one this week: Click here to listen to your hint. What could it be? Leave your answers in the comment section. I’ll confirm any correct answer over the weekend.

Still Confused about siRNA vs. miRNA?

Here is an illustration from a recent PLoS Biology paper: Two complexes: 1- miRNA. Imperfect base pairing between the small RNA and the target. This complex sorts the RNA to p-bodies (processing bodies) where other proteins join in. The mRNA is either destroyed or stored. 2- siRNA. Perfect base pairing. The mRNA is destroyed and…

Colin McGinn Video

Wow – a creationist was appointed to high level position in the Conservative government back home. On the other side of the line Richard Dawkins has set up a foundation to promote acceptance of atheists (Richard, you better open a franchise in Ottawa.) Speaking of the RDF (Richard Dawkins Foundation) there are great videos available…

Thomson Scientific Nobel Predictions

Someone yesterday asked whether there were online odds for the upcoming Nobels? Well Thomson Scientific (producers of ISI and other citation indices) have their own predictions and a poll too (although they only give 3 choices???) Medicine & Physiology predictions (by Thomson Sci): For more speculation on the Nobels (including my pics and the pics…

mRNA expression in mammalian cells

Newest from PLoS Biology: Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S Stochastic mRNA Synthesis in Mammalian Cells. PLoS Biol (2006) 4(10): e309 The authors genomically incorporated a gene with 32 tandem copies of a 43-base-pair probe-binding sequence at the 3′ end of a coding sequence for a fluorescent protein into CHO (chinese…

Who will win this year? Some guesses for the Medicine & Physiology (or perhaps Chemistry) below the fold. Warning – the guesses presented here are highly biased towards cellular physiology.

Survivor – Lab Edition

(What follows was started at The Sunburnt Cow, an Australian Bar/Restaurant in Alphabet City – over a brunch that included unlimited Mimosas, Bloody Marys, Fosters and Vegemite.) Here is the hypothetical situation: It’s the end of the world. You are barricaded in your lab. You have unlimited access to water. What lab supplies can you…

Just came back from New York. As usual we met up with the old crew and had a blast. On Saturday we stopped by Korea Town (32nd Street) for some kimchi. Sitting down, we saw this: Kimchi from GMO bacteria!

Why? You can find treasures there. I once owned this book, then lent it to a friend who is now studying place cells in Bristol, UK. (Bruno you can keep the book.)