Depressing
Category: Lab Life
... when you finish your experiment at 5:15PM then exit the microscope room and discover that it's pitch dark outside....
Posted by Alex Palazzo at 5:20 PM • 6 Comments • 0 TrackBacks
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Alex Palazzo is a postdoctoral fellow working in the Department of Cell Biology at Harvard Medical School.
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October 31, 2006
How the hell does dynamin act to fuse membranes?
Category: Pure Biology
Jodi Nunnari's group has a paper in Cell about how Mgm1, a dynamin like protein found in the inner mitochondrial matrix, is required for inner-membrane fusion in mitos.
Posted by Alex Palazzo at 2:18 PM • 5 Comments • 0 TrackBacks
The Moral Mind - NY Times Comment
Category: Misc
Just as Chomsky argued that we are endowed with a language instinct, Hauser proposes that we all have a morality instinct. In today's NY Times there is an article on his new book:
Posted by Alex Palazzo at 8:11 AM • 1 Comments • 0 TrackBacks
October 28, 2006
Saturday Morning Video
Category: art, food, music, citylife and other mental stimuli
Campaign ads? The whole thing reminds me of a Frank Zappa song.
Posted by Alex Palazzo at 10:50 AM • 0 Comments • 0 TrackBacks
October 27, 2006
Letting Go of God
Category: art, food, music, citylife and other mental stimuli
Last night I saw Julia Sweeney's Letting Go of God at the Sander's theatre. It was a great show. I won't go into too many details, but just to let you know, it's a longer version of the monologue that...
Posted by Alex Palazzo at 4:45 PM • 5 Comments • 0 TrackBacks
Spending Money in a Biomedical Lab
Category: Lab Life
What type of biomedical research costs the most? That is an interesting question. With the NIH asking for a 20% cut in everyone's grant, our lab has been looking into who spends what, and where can we cut costs. An...
Posted by Alex Palazzo at 3:05 PM • 12 Comments • 0 TrackBacks
Map That Campus XX
Category: Map that Campus
Yes, it's back. And for the 20th edition we have a nice pair for you. Any ideas on who they could be?
Posted by Alex Palazzo at 10:52 AM • 7 Comments • 0 TrackBacks
October 26, 2006
The Best Science Television Show?
Category: Ask a ScienceBlogger
Born and raised in Canada, I have to say that there is one obvious choice: The Nature of Things. Almost every Canadian in my age group has a picture of David Suzuki seared on some part of their neocortex.
Posted by Alex Palazzo at 5:28 PM • 4 Comments • 0 TrackBacks
Some Thoughts on Mitosis & Cancer
Category: Pure Biology
At that same meeting over the past weekend, I heard Tim Mitchison give an interesting talk about mitosis and pharmacogenetics. For any of you who don't know, Tim's lab has been at the fore front of analyzing how the mitotic...
Posted by Alex Palazzo at 1:02 PM • 4 Comments • 0 TrackBacks
October 25, 2006
Why is every protein expressed in testes?
Category: Pure Biology
Does this type of expression profile look familiar? From my limited experience from these types of pan-tissue blots, it would seem like every damn protein is expressed in testes. Why?...
Posted by Alex Palazzo at 10:10 AM • 11 Comments • 0 TrackBacks
October 23, 2006
Drugs + Genetics
Category: Pure Biology
When manipulating the constituents of a living organism we can revert to several methods. Specificity and temporal resolution are both critical. How to get the best of both worlds?
Posted by Alex Palazzo at 8:49 AM • 2 Comments • 0 TrackBacks
October 20, 2006
Mission Accomplished!
Category: Lab Life
Well I'm packing up to go off to western Connecticut for my fellowship retreat. Oh yeah, about that last minute experiment ... I nailed it! Not only did the experiment work but I also got the anticipated result confirming my...
Posted by Alex Palazzo at 11:31 AM • 4 Comments • 0 TrackBacks
October 18, 2006
The things you miss when your you're madly working in the lab till 1AM
Category: Misc
Dawkins on The Colbert Report.
Posted by Alex Palazzo at 5:33 PM • 3 Comments • 0 TrackBacks
October 17, 2006
Synchronized Swimming Mitosis
Category: Lab Life
Sorry I'm not updating often. I've got a meeting this weekend and I'm trying to get that last piece of data (I know it sounds cliche, but face it, we all do it). What makes it worse is that my...
Posted by Alex Palazzo at 11:16 PM • 4 Comments • 0 TrackBacks
October 16, 2006
A sign from above the 49th parallel
Category: Misc
Cuz' all of our signs are bilingual....
Posted by Alex Palazzo at 3:49 PM • 4 Comments • 0 TrackBacks
The manuscript that haunts me
Category: Lab Life
It's not one of mine, waiting to be completed. It's not from a competitor, scooping my precious results. It doesn't even have much impact on my own work. No it's a paper I once printed, and have heard about from...
Posted by Alex Palazzo at 11:44 AM • 3 Comments • 0 TrackBacks
October 13, 2006
Yeast - The Republicans of the Eukaryotic Kingdom?
Category: Lab Life
Yeah ... it's Friday afternoon and this was stimulated by our happy hour.
Posted by Alex Palazzo at 6:36 PM • 3 Comments • 0 TrackBacks
New Technique to Control Protein Expression
Category: Pure Biology
One of the problems in modern day biomedical research is turning on/off protein expression. Now there is a new method that combines protein degradation and pharmacology.
Posted by Alex Palazzo at 3:44 PM • 4 Comments • 0 TrackBacks
Map That Campus XIX
Category: Map that Campus
What could it be?
Posted by Alex Palazzo at 8:29 AM • 8 Comments • 0 TrackBacks
October 12, 2006
Another Shocking Statistic
OK this is officially quantitation week on The Daily Transcript. Today's number is provided by Gilbert Burnham's group at The John Hopkins: 655,000 deaths due to the Iraqi war. From the Globe and Mail:...
Posted by Alex Palazzo at 10:55 AM • 6 Comments • 0 TrackBacks
October 11, 2006
Yet even more numbers
Category: Science & Society
Top 10 cities in university research spending in the US.
Posted by Alex Palazzo at 11:47 AM • 3 Comments • 0 TrackBacks
Some more rankings
Category: Education
... of world universities by the The London Times.
Posted by Alex Palazzo at 8:31 AM • 4 Comments • 0 TrackBacks
October 10, 2006
Getting Drunk on Actin
Category: Pure Biology
I just read at ScienceSampler that interfering with actin polymerization enhances ethanol tolerance. If only I knew. The only question left is that will it cure your hangover?
Posted by Alex Palazzo at 11:32 AM • 0 Comments • 0 TrackBacks
October 6, 2006
Map that Campus XVIII
Category: Map that Campus
What could it be this week?
Posted by Alex Palazzo at 9:28 AM • 4 Comments • 0 TrackBacks
October 5, 2006
The Sixteenth 1st Annual Ig Nobels Tonight
Category: Lab Life
OK now that the Science Nobels have been distributed it's time for the real awards to begin, the Ig Nobels. How big is the Ig Nobel? It's janitor won last year's Nobel for Physics! If you're in the Boston area,...
Posted by Alex Palazzo at 11:56 AM • 0 Comments • 0 TrackBacks
October 4, 2006
Jesus Gel
Category: Misc
Yesterday someone on our floor announced "I see Jesus!" Really? Then we saw his image on the left side of a silver-stained polyacrylamide gel: Upon closer inspection it looked like his face was partially obscured by some proteins....
Posted by Alex Palazzo at 12:02 PM • 15 Comments • 0 TrackBacks
Transcription Wins Chemistry Nobel!
Category: Science & Society
If you need to know ANYTHING about biology remember: DNA =(transcription)=> RNA =(translation)=> Protein. Well today the Nobel Prize went to Roger Kornberg of Stanford for the structure of the first process. The Nobel's press release (pdf). It's official, RNA...
Posted by Alex Palazzo at 8:36 AM • 13 Comments • 0 TrackBacks
October 3, 2006
Best Places to Work in 2006: Academia
Category: Lab Life
Here is the annual list from The Scientist. (Click here for the article.)...
Posted by Alex Palazzo at 3:14 PM • 2 Comments • 0 TrackBacks
The newest ad in our lunchroom
Category: Lab Life
It's not as deranged as the last one. It must be for biotechs and pharma as "Get Promoted" and "Batch Released" do not really apply to this lab....
Posted by Alex Palazzo at 9:38 AM • 0 Comments • 0 TrackBacks
October 2, 2006
RNAi from Petunias to Worms
Category: Pure Biology
OK a breif history of RNA interference. 1990 Rich Jorgensen at the University of Arizona wanted to make petunias a deeper purple. His group tried expressing extra copies of the same gene and ... he got white flowers. The very...
Posted by Alex Palazzo at 7:50 PM • 4 Comments • 0 TrackBacks
Correction on Centrosomal RNA
Category: Pure Biology
About a month ago I wrote an entry on centrosomal RNA. Turns out that the work was not "out of Bob Palazzo's lab" as I asserted but from Mark Alliegro's Lab. His lab has been working on this project for...
Posted by Alex Palazzo at 4:50 PM • 0 Comments • 0 TrackBacks
Nobel for RNA Interference!
Category: Pure Biology
We all thought that it was a bit early, but VERY deserved. Also can I add this: The Daily Transcript 1: Thomson Scientific 0. For anyone not in the basic biomedical sciences, the two biggest revolutions in the past 10...
Posted by Alex Palazzo at 10:11 AM • 10 Comments • 0 TrackBacks
