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Alex Palazzo is a postdoctoral fellow working in the Department of Cell Biology at Harvard Medical School.

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October 31, 2006

Depressing

Category: Lab Life

... when you finish your experiment at 5:15PM then exit the microscope room and discover that it's pitch dark outside....

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How the hell does dynamin act to fuse membranes?

Category: Pure Biology

Jodi Nunnari's group has a paper in Cell about how Mgm1, a dynamin like protein found in the inner mitochondrial matrix, is required for inner-membrane fusion in mitos.

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The Moral Mind - NY Times Comment

Category: Misc

Just as Chomsky argued that we are endowed with a language instinct, Hauser proposes that we all have a morality instinct. In today's NY Times there is an article on his new book:

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October 28, 2006

Saturday Morning Video

Category: art, food, music, citylife and other mental stimuli

Campaign ads? The whole thing reminds me of a Frank Zappa song.

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October 27, 2006

Letting Go of God

Category: art, food, music, citylife and other mental stimuli

Last night I saw Julia Sweeney's Letting Go of God at the Sander's theatre. It was a great show. I won't go into too many details, but just to let you know, it's a longer version of the monologue that...

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Spending Money in a Biomedical Lab

Category: Lab Life

What type of biomedical research costs the most? That is an interesting question. With the NIH asking for a 20% cut in everyone's grant, our lab has been looking into who spends what, and where can we cut costs. An...

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Map That Campus XX

Category: Map that Campus

Yes, it's back. And for the 20th edition we have a nice pair for you. Any ideas on who they could be?

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October 26, 2006

The Best Science Television Show?

Category: Ask a ScienceBlogger

Born and raised in Canada, I have to say that there is one obvious choice: The Nature of Things. Almost every Canadian in my age group has a picture of David Suzuki seared on some part of their neocortex.

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Some Thoughts on Mitosis & Cancer

Category: Pure Biology

At that same meeting over the past weekend, I heard Tim Mitchison give an interesting talk about mitosis and pharmacogenetics. For any of you who don't know, Tim's lab has been at the fore front of analyzing how the mitotic...

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October 25, 2006

Why is every protein expressed in testes?

Category: Pure Biology

Does this type of expression profile look familiar? From my limited experience from these types of pan-tissue blots, it would seem like every damn protein is expressed in testes. Why?...

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October 23, 2006

Drugs + Genetics

Category: Pure Biology

When manipulating the constituents of a living organism we can revert to several methods. Specificity and temporal resolution are both critical. How to get the best of both worlds?

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October 20, 2006

Mission Accomplished!

Category: Lab Life

Well I'm packing up to go off to western Connecticut for my fellowship retreat. Oh yeah, about that last minute experiment ... I nailed it! Not only did the experiment work but I also got the anticipated result confirming my...

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October 18, 2006

The things you miss when your you're madly working in the lab till 1AM

Category: Misc

Dawkins on The Colbert Report.

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October 17, 2006

Synchronized Swimming Mitosis

Category: Lab Life

Sorry I'm not updating often. I've got a meeting this weekend and I'm trying to get that last piece of data (I know it sounds cliche, but face it, we all do it). What makes it worse is that my...

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October 16, 2006

A sign from above the 49th parallel

Category: Misc

Cuz' all of our signs are bilingual....

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The manuscript that haunts me

Category: Lab Life

It's not one of mine, waiting to be completed. It's not from a competitor, scooping my precious results. It doesn't even have much impact on my own work. No it's a paper I once printed, and have heard about from...

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October 13, 2006

Yeast - The Republicans of the Eukaryotic Kingdom?

Category: Lab Life

Yeah ... it's Friday afternoon and this was stimulated by our happy hour.

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New Technique to Control Protein Expression

Category: Pure Biology

One of the problems in modern day biomedical research is turning on/off protein expression. Now there is a new method that combines protein degradation and pharmacology.

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Map That Campus XIX

Category: Map that Campus

What could it be?

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October 12, 2006

Another Shocking Statistic

Category:

OK this is officially quantitation week on The Daily Transcript. Today's number is provided by Gilbert Burnham's group at The John Hopkins: 655,000 deaths due to the Iraqi war. From the Globe and Mail:...

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October 11, 2006

Yet even more numbers

Category: Science & Society

Top 10 cities in university research spending in the US.

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Some more rankings

Category: Education

... of world universities by the The London Times.

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October 10, 2006

Getting Drunk on Actin

Category: Pure Biology

I just read at ScienceSampler that interfering with actin polymerization enhances ethanol tolerance. If only I knew. The only question left is that will it cure your hangover?

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October 6, 2006

Map that Campus XVIII

Category: Map that Campus

What could it be this week?

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October 5, 2006

The Sixteenth 1st Annual Ig Nobels Tonight

Category: Lab Life

OK now that the Science Nobels have been distributed it's time for the real awards to begin, the Ig Nobels. How big is the Ig Nobel? It's janitor won last year's Nobel for Physics! If you're in the Boston area,...

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October 4, 2006

Jesus Gel

Category: Misc

Yesterday someone on our floor announced "I see Jesus!" Really? Then we saw his image on the left side of a silver-stained polyacrylamide gel: Upon closer inspection it looked like his face was partially obscured by some proteins....

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Transcription Wins Chemistry Nobel!

Category: Science & Society

If you need to know ANYTHING about biology remember: DNA =(transcription)=> RNA =(translation)=> Protein. Well today the Nobel Prize went to Roger Kornberg of Stanford for the structure of the first process. The Nobel's press release (pdf). It's official, RNA...

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October 3, 2006

Best Places to Work in 2006: Academia

Category: Lab Life

Here is the annual list from The Scientist. (Click here for the article.)...

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The newest ad in our lunchroom

Category: Lab Life

It's not as deranged as the last one. It must be for biotechs and pharma as "Get Promoted" and "Batch Released" do not really apply to this lab....

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October 2, 2006

RNAi from Petunias to Worms

Category: Pure Biology

OK a breif history of RNA interference. 1990 Rich Jorgensen at the University of Arizona wanted to make petunias a deeper purple. His group tried expressing extra copies of the same gene and ... he got white flowers. The very...

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Correction on Centrosomal RNA

Category: Pure Biology

About a month ago I wrote an entry on centrosomal RNA. Turns out that the work was not "out of Bob Palazzo's lab" as I asserted but from Mark Alliegro's Lab. His lab has been working on this project for...

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Nobel for RNA Interference!

Category: Pure Biology

We all thought that it was a bit early, but VERY deserved. Also can I add this: The Daily Transcript 1: Thomson Scientific 0. For anyone not in the basic biomedical sciences, the two biggest revolutions in the past 10...

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