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Alex Palazzo is a postdoctoral fellow working in the Department of Cell Biology at Harvard Medical School.

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December 31, 2006

The (de/re)cline of the american empire.

Category: art, food, music, citylife and other mental stimuli

(This is back dated as I would like to start the new year on a brighter note.) After a long day of skiing in the green hills of Vermont, my brother , cousin and I decided to go for a...

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December 29, 2006

Map that Campus XXVIII

Category: Map that Campus

Last one for this year.

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December 28, 2006

At home wasting time ...

Category: art, food, music, citylife and other mental stimuli

(I wish) I though I could spend a day or too relaxing ... but it seems like I can't do it. Today was spent cleaning the apartment in preparation for a family visit down from Montreal. We're actually meeting up...

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December 27, 2006

RNA, 50 years in the making

Category: Pure Biology

2006 was (again) year of the RNA. Two nobels. The RNA world expanded with the discovery of Piwi RNA. RNAi as a transmittable trait? (Lamarck is vindicated!) We also found out that much of the conserved parts of our genome...

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December 26, 2006

My year in a picture

Category: art, food, music, citylife and other mental stimuli

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December 24, 2006

(Almost*) First Clinical Trial with RNA Aptamers

Category: Pure Biology

Check this out: First-in-Human Experience of an Antidote-Controlled Anticoagulant Using RNA Aptamer Technology From the paper:...

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December 23, 2006

Quote of the week

Category: Science & Society

... I was listening to NPR where they were discussing the bonus that Goldman Sachs gave to its CEO, Lloyd C. Blankfein, a record of $53.4 Million. Some one called to say...

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A silent mutation affects pain perception?

Category: Pure Biology

Earlier this week you probably read the whole saga of how researchers tracked down some individuals who could not sense pain. They then identified the gene responsible as SCN9A, a voltage-gated sodium channel and that was published in Nature. But...

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December 20, 2006

Tid Bits

Category: Misc

Chris Phoenix asked me to comment on his entry: Studying Molecular Biology. As someone who is constantly playing around with cells I'll add this advice to how biological systems differ from watches and the Antikythera Mechanism, biological systems are composed...

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December 19, 2006

A weekend in NYC

Category: art, food, music, citylife and other mental stimuli

Last week was too stressful - although by Friday afternoon I had put together the pieces of the puzzle and it all makes sense (I'd tell you more about it, potentially I've stumbled upon a really cool little "cellular circuit",...

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December 15, 2006

Map that Campus XXVII

Category: Map that Campus

Another week, another mystery campus ...

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December 14, 2006

Quote of the Day

Category: art, food, music, citylife and other mental stimuli

From Kazuo Ishiguro's Never Let Me Go.

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December 13, 2006

Happiness in the lab

Category: Lab Life

Here's a happiness scale for you. Add your own lab experiences with the appropriate number.

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Biochemistry with the stars

Category: Science & Society

Check out the video here. [HT: kscs]...

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Stress

Category: Lab Life

Time for a therapy session. Man I hate this. My cortisol levels must be through the roof. I tested my clones and got weird results. I was racking my brain all weekend trying to figure out why. Then yesterday I...

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December 12, 2006

Different types of signal sequences?

Category: Pure Biology

Apparently weak and strong signal sequences are differentially targeted to the ER acording to a new paper in Cell.

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December 9, 2006

Tid bits

Category: Misc

Baltimore on Dawkins. Three kingdoms? Skeptical publishing. Integrins & migration. Libertarians & adolescents? Kant vs. Archimedes. Yes they're all below the fold.

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December 8, 2006

Melissa Moore on Introns

Category: Pure Biology

Yesterday Melissa Moore gave a talk at the School of Public Health here at Harvard Med School. She had lots of data - on nonsense mediated decay (how cells degrade mRNA transcripts with premature stop codons that arise through various...

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Map that Campus XXVI

Category: Map that Campus

It's that time again. Here is this week's mystery campus: hint: fatal element. As usual, leave your answers in the comment section....

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December 7, 2006

Cloning Karma

Category: Lab Life

... is with me. Two constructs to make. Two colonies I had. Each trial a single clone. I cut them, they cut just the way I hoped. Each clone was sequenced. The sequence told me that I have what I...

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December 6, 2006

Ribosome-SRP-Signal Sequence Structures

Category: Pure Biology

Wow, this is how the machine works!

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Short List for Larry Summers' Replacement

Category: Science & Society

From today's Boston Globe: Harvard has whittled down hundreds of nominees for its next president to a small list, including internal candidates and presidents of some of the nation's top universities, according to a source familiar with the process. The...

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December 4, 2006

H-Index + Google = Scientific Rankings Gone Crazy

Category: Lab Life

The H-index was the brainchild of Jorge Hirsch. It's a method to quantify a researchers impact. (To read more on this, check this entry of mine: What's your h-index.) I was just alerted that Michael Schwartzbach has written a program...

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How proteins cross the Nuclear Pore Complex

Category: Pure Biology

FG repeats found within the nuclear pore complex, form a gel like matrix. It's all nicely explained in a manuscript that recently appeared in Science.

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December 3, 2006

Out of nowhere

Category: Misc

... came Stephane Dion to take the leadership of the Liberal Party in Canada. Dion's platform ... (from the CBC) "We cannot afford to miss out on the next industrial revolution: the sustainable economy," Dion said when he announced his...

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December 1, 2006

RNA Export Diagram

Category: Pure Biology

Earlier today I gave our weekly journal club. As usual there is some large scheme/model/godzilla image associated with the intro/summary. Here's mine ... mRNA nuclear export in yeast: Highlighted are 3 major systems. Many proteins are listed, many more are...

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Map that Campus XXV

Category: Map that Campus

What could it be? Come give it your best shot.

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