Transcription and Translation

2

Yeah, I still completely disagree with that statement. It's never wrong to have some focus in your work. If one protein is a gateway to a field, then study that one protein.

Posted by: U | February 13, 2007 12:21 AM

4

Do they even read primary literature?

Some of them do. The problem is that they don't understand it. It would be much better if they would read some uptodate biology textbook first. And with reading I indeed do mean that they should work through it because there are good reasons why studying biology takes some years.

Posted by: sparc | February 13, 2007 2:59 AM

6

couldn't agree more with your last comment Alex... sure the focus maybe one gene, one protein... but it is the context that should be the focus, even for structural biologists, they should adhere to some sensibilities and choose subjects of current scientific interest rather than the easiest protein to crystalise/purify etc... More crossover of skills/appreciation for structure-function and system biology approaches wouldn't go amiss!

Posted by: Kirklain | February 13, 2007 11:41 AM

8

In his 2002 Nobel Lecture NATURE'S GIFT TO SCIENCE Sidney Brenners said that he had the idea of distinguishing junk from garbage in the 80's:

In 1985, when the first suggestions were made to sequence the human genome, I thought that the sequencing techniques, even with incremental improvements, would not be equal to the task, and would require a factory scale operation to do it. I had also come to the conclusion that most of the human genome was junk, a form of rubbish which, unlike garbage, is not thrown away. My view at the time was that we should treat the human genome like income tax and find every legitimate way of avoiding sequencing it. It could therefore be asked whether a genome existed in Nature which perhaps had very much less junk but nevertheless had the full repertoire of vertebrate genes?

Hwa A Lim's book GENETICALLY YOURS - Bioinforming, Biopharming, and Biofarming (World Scientific Publishing, online available here: http://www.worldscibooks.com/lifesci/etextbook/4950/4950_chap1_4.pdf ) presents this Brenner statement:

In the words of Sydney Brenner, then director of Molecular Genetics Institute at Cambridge, "More than 95% of the DNA is junk. But let me point out that it's not garbage because the difference between junk and garbage is exactly the same difference you make. Garbage you throw away and junk you keep because you think you might want to do something useful with it, and of course you never do. So, 95%, or more than 95% is junk, and I think that is a valid argument to say against the idea of sequencing the entire genome, because we'd spend a lot of time doing this. Against this, people said, well, you don't know until you've done it whether it is or isn't junk."

and gives the following reference "Decoding the Book of Life", NOVA, WGBH Educational Foundation, October 31, 1989. WGBH seems to be a radio program. Thus, he developed his idea during the mid 80's.

Posted by: sparc | February 13, 2007 2:20 PM

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I don’t know about the rest of you, but I’ve always found the term “junk DNA” to be appropriate. If you look up the word ‘junk’ for instance in the dictionary, you find:

1. Discarded material, such as glass, rags, paper, or metal, some of which may be reused in some form.

Word History: The word junk is an example of the change in meaning known as generalization, and very aptly too, since the amount of junk in the world seems to be generalizing and proliferating rapidly. The Middle English word jonk, ancestor of junk, originally had a very specific meaning restricted to nautical terminology. First recorded in 1353, the word meant “an old cable or rope.” On a sailing ship it made little sense to throw away useful material since considerable time might pass before one could get new supplies. Old cable was used in a variety of ways, for example, to make fenders, that is, material hung over the side of the ship to protect it from scraping other ships or wharves. Junk came to refer to this old cable as well. The big leap in meaning taken by the word seems to have occurred when junk was applied to discarded but useful material in general. This extension may also have taken place in a nautical context, for the earliest, more generalized use of junk is found in the compound junk shop, referring to a store where old materials from ships were sold. Junk has gone on to mean useless waste as well.

So while “junk” even in the colloquial sense can refer to something useless, it does not necessarily have to be useless. Pretty much everyone here has a junk drawer or an area where you have a pile of junk, perhaps the attic or garage or both. You don’t save this stuff because it’s worthless garbage, do you? The reason you save this ‘junk’ at all is precisely because it may have some use down the road that you can’t envision at the moment. And it did have a use at some point but is no longer used for the original purpose, perhaps because it’s broken, which is how it found itself in your junk pile in the first place. This is analogous to pseudogenes, which are similar to functional genes by have a mutation that makes them ‘broken’ but are still hanging around and may (or may not) eventually be found useful for some other purpose.

Finding a use for a piece of “junk DNA” no more validates the claim that it’s all really not junk, any more than does using that empty film container to hold thumbtacks mean the rest of the stuff in the drawer is no longer really junk.

Posted by: Dave S. | February 13, 2007 3:20 PM

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This was a very useful post. I encourage the discouragement of creationist nonsense.

Check out this creationist webpage: http://drdino.com

Posted by: Adrian Clement | March 25, 2007 6:43 PM