Read this stem cell paper!
Category: Pure Biology
Soon it will be clear that this paper from last summer will be the basis of a future Nobel Prize.
Posted by Alex Palazzo at 6:59 PM • 21 Comments •
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Alex Palazzo is a postdoctoral fellow working in the Department of Cell Biology at Harvard Medical School.
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May 31, 2007
May 30, 2007
Here today, gone tomorrow
Category: Lab Life
Rumour has it that last week a junior faculty here at Harvard Medical School showed up to his lab and with no prior warning announced that he was leaving academic science. The next day he was gone. All of his...
Posted by Alex Palazzo at 3:15 PM • 6 Comments •
'cuz it's my b'day
Category: art, food, music, citylife and other mental stimuli
Some Tom Waits:...
Posted by Alex Palazzo at 8:47 AM • 6 Comments •
Pinker on Scientific Literacy
Category: Science & Society
This past weekend in a review of Natalie Angier's new book Steven Pinker wrote something I'd like to share with you (below the fold):...
Posted by Alex Palazzo at 8:27 AM • 5 Comments •
May 28, 2007
Second Call for Mendel's Garden #15
Category: Misc
Have a great entry on genetics, genes, evolution, cell biology or any other relevant topic? The 15th edition of Mendel's Garden is now requesting entries. You have until June 2nd to send 'em in. Just email me or submit them...
Posted by Alex Palazzo at 8:59 AM • 0 Comments •
May 26, 2007
Saturday Morning Video - Cordyceps & Ants
Category: Science & Society
Here is an amazing clip from BBC's Planet Earth demonstrating the life cycle of a member of the Cordyceps family of parasitic fungi.
Posted by Alex Palazzo at 8:36 AM • 6 Comments •
May 25, 2007
Green Fluorescent Protein - A Jennifer Lippincott-Schwartz Videocast
Category: Pure Biology
Hear a seminar from one of the pioneers of GFP technology and a leader in the study of cellular organelles.
Posted by Alex Palazzo at 8:29 AM • 6 Comments •
May 24, 2007
A Little Note on Complexity in Humans
Category: Pure Biology
This is a cleaned up version of a comment I left on Larry Moran's blog....
Posted by Alex Palazzo at 7:44 PM • 4 Comments •
May 23, 2007
What happens when you try to do too many things ...
Category: Lab Life
After picking colonies, preparing DNA samples from them, digesting a small aliquot of the plasmid prep with the appropriate restriction enzymes and preparing an agarose gel ... you end up loading your minipreps instead of your restriction digests. Damn....
Posted by Alex Palazzo at 8:55 AM • 12 Comments •
Stanley Miller (1930-2007)
Category: Science & Society
Stanley Miller, of the famed Urey-Miller experiment, died Sunday (NYTimes Obit). Here's an entry from over a year ago that was catalyzed by a conversation with a former member of the Miller lab:...
Posted by Alex Palazzo at 7:13 AM • 1 Comments •
May 22, 2007
70% of the genome is transcribed - then what?
Category: Pure Biology
A new hint in the latest issue of Cell.
Posted by Alex Palazzo at 12:14 PM • 10 Comments •
Quote of the Day
Category: Lab Life
Overheard in the hallway: First postdoc: I have basically wasted a year. Second postdoc (muttering to himself): I wasted a decade....
Posted by Alex Palazzo at 11:12 AM • 1 Comments •
A Note on Centrioles, Basal Bodies & Cilia
CCP asks What is the phylogenetic distribution of centrioles? Does it match that of cilia / flagella? Just to summarize what all these cellular structures are, centrioles are distinct structures found in most eukaryotic cells. They are composed of nine...
Posted by Alex Palazzo at 8:44 AM • 0 Comments •
May 21, 2007
A riboswitch regulates alternative splicing in eukaryotes!
Category: Pure Biology
A few days ago I wrote about Ron Breaker and Riboswitches, and today I was alerted to this really neat advanced online publication by the Breaker group on how a riboswitch in Neurospera regulates alternative splicing. Wow. So what...
Posted by Alex Palazzo at 9:06 PM • 0 Comments •
De Novo Centrioles
Category: Pure Biology
So is the theory of semi-conservative replication of centrioles dead?
Posted by Alex Palazzo at 5:22 PM • 2 Comments •
May 20, 2007
Tid Bits
Category: Misc
A Sunday morning linkfest for you.
Posted by Alex Palazzo at 11:16 AM • 1 Comments •
May 19, 2007
Mendel's Garden #15 - Call for Submissions
Category: Misc
Also update your link to Mendel's Garden. Here is some code that you can cut & paste into your template.
Posted by Alex Palazzo at 11:49 AM • 1 Comments •
Saturday Morning Video
Category: Science & Society
Lab work made sexy on primetime? Don't you hate it when your BLAST searches turn up nothing!...
Posted by Alex Palazzo at 8:40 AM • 1 Comments •
May 18, 2007
Article on the Riboswitches and general RNA talk
Category: Lab Life
Over coffee we were flipping through the May edition of the Howard Hughes Medical Institute's Newsletter when we saw an article on riboswitches, RNA aptamers and the RNA World. The piece features Ron Breaker from Yale, who is most known...
Posted by Alex Palazzo at 4:57 PM • 2 Comments •
Stem Cell Research on Charlie Rose
Category: Science & Society
The video is here, with Paul Nurse, Doug Melton, George Daley, Larry Goldstein, and Story Landis.
Posted by Alex Palazzo at 7:58 AM • 0 Comments •
May 17, 2007
To all you microscopist wannabes, I've got something for you
Category: Lab Life
Time for a rant. Inspired by a great commentary in Nature that any budding microscopist should read.
Posted by Alex Palazzo at 5:26 PM • 10 Comments •
May 16, 2007
New England RNA Data Club - The Day After
Category: Lab Life
It was great (except for that darn thermostat ...)
Posted by Alex Palazzo at 11:19 AM • 3 Comments •
Carboxy-Tail-Anchored Proteins
Category: Pure Biology
How are these inserted into membranes? Another fundamental biological activity that up until recently had been a mystery.
Posted by Alex Palazzo at 8:33 AM • 0 Comments •
May 15, 2007
New England RNA Data Club Today!
Category: Lab Life
Wow, what a week. I finally submitted my paper to PLoS Biology and we finally got our RNA Data Club up and going. This event/series was conceived in a drunken state at a happy hour about 1&1/2 months ago and...
Posted by Alex Palazzo at 9:22 AM • 3 Comments •
May 14, 2007
Quote of the day
Category: Lab Life
From an email I just received: RNA Processing Group (RPG) is intended solely for the person(s) who genuinely believe that RNA research is the coolest thing in the world. To become a member, you have to openly claim that RNA...
Posted by Alex Palazzo at 3:10 PM • 8 Comments •
May 11, 2007
FASEB: Urge Congress to Support the NIH and NSF
Category: Lab Life
Sign this online petition and send it to your US Senators and US House Representative.
Posted by Alex Palazzo at 3:42 PM • 2 Comments •
Paper Submitted!
Category: Lab Life
But this is no time to rest ... Tuesday I'm giving the first talk of our inaugural New England RNA Data Club (yes we've renamed it to the New England RNA Data Club ... we're having folks from out of...
Posted by Alex Palazzo at 8:59 AM • 1 Comments •
May 9, 2007
When you're hot, you're ...
Category: Lab Life
I once made an offer to this guy that I'd word for him if he offered me a permanent postdoc position with a 100% pay raise. Now everywhere I turn, I see his face. Open Nature, and there are back...
Posted by Alex Palazzo at 2:21 PM • 0 Comments •
How auxin works (with a little help from IP6)
Category: Pure Biology
Auxin is a major plant signaling molecule. Ning Zheng's lab shows how it works with IP6 to degrade molecules. In the process we learn a new concept: molecular glue.
Posted by Alex Palazzo at 8:40 AM • 4 Comments •
May 6, 2007
Oh, the wonders of modern robotics
Keepon the interactive dancing robot. Videos and specs here.
Posted by Alex Palazzo at 10:40 AM • 7 Comments •
May 5, 2007
The Difference Between Biotech in Boston and NYC
Category: Lab Life
We arrived in New York last night and we joined a friend for dinner in Williamsburg at a joint called Tacu Tacu, a Peruvian/Thai place (they had an excellent ceviche platter). Eventually talk drifted to biotechs. Apparently Bloomberg in collaboration...
Posted by Alex Palazzo at 9:45 AM • 3 Comments •
May 4, 2007
Plasmodium is just like a shmooing yeast cell
Category: Pure Biology
Let's put it this way, if animals, plants and fungi are three siblings, Plasmodium would be their 6th cousin who lives in a trailer-park on the other side of the river. It's a distant relative, but deep down they're all related in an uncanny way.
Posted by Alex Palazzo at 8:49 AM • 1 Comments •
May 3, 2007
Article in Cell on Science Blogs
Category: Lab Life
There's a little "Leading Edge" review by Laura Bonetta on scientists who blog. I spoke to her last week and some of our conversation is in the peice. Some other ScienceBlogs mentioned are A Blog Around the Clock, Pharyngula, Aetiology,...
Posted by Alex Palazzo at 10:59 AM • 2 Comments •
Video on a Cancer Research Pioneer - Karl Heinrich Bauer
Here's a link to the video....
Posted by Alex Palazzo at 9:30 AM • 0 Comments •
May 2, 2007
Name that fungi
Category: Pure Biology
Can you identify the mystery organism that causes Joolya's tissue culture cells to bleb?
Posted by Alex Palazzo at 6:02 PM • 0 Comments •
More on prokaryote organelles
Category: Pure Biology
A bacterium with a nucleiod membrane.
Posted by Alex Palazzo at 5:41 PM • 5 Comments •
May 1, 2007
HDACs
Category: Pure Biology
I had never seen Eric Olson's seminar before, and it was awesome. Lately the Olson's lab has been looking at HDACs, i.e. histone deacetylases. Knockouts of these proteins are really fascinating.
Posted by Alex Palazzo at 7:41 PM • 1 Comments •
