Pure Biology

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Category archives for Pure Biology

Gairdner Talks Begin

Well this week the University of Toronto hosts the 50th anniversary of the Gairdner Foundation. If the Nobels are the Oscars of science, and the Lasker Awards the Golden Globes, this event is akin to the 50th anniversary of some big Hollywood studio. There are talks by many of today’s hottest science rock stars and…

Discussion with a Cancer Surgeon

This weekend, I had the opportunity to sit down with a friend, a cancer surgeon who works at a major teaching hospital in the US. He, his wife and two kids were up visiting us for the weekend. Over coffee, I was asking him about the state of cancer therapeutics. Although he himself does not…

Link love – RNA Nobels Edition

Well this year was a big year again for RNA at the Nobels. Both prizes were essentially given to RNA dependent processes. In the case of Telomerase, an RNA molecule, Telomerase RNA (hTR or TERC), acts as the template strand to help Telomerase Reverse Transcriptase (TERT) elongate the end of the telomere. Here’s a great…

All Your Ribosomes Belong to Us

So more than a week has gone by and there has been little press about the science Nobels. And I must say that this year’s Medicine and Chemistry prizes are some of the most important in quite a while. But even between the two, the Chemistry is especially important. Why? I’m not sure. Maybe they…

Quote of the Day

Unraveling the ribosome is one of science’s Holy Grails. Were God a molecule, he or she would be a ribosome, a veritable galaxy of atoms whose job is to translate genetic code into the stuff of life–protein. – Brian Maffly, reporter for the Slt Lake Tribune in a recent article, Ramakrishnan: Nobel-winning work started in…

Next RNA Data Club, March 4th

Well after a bit of a holiday, the New England RNA Data Club is back. We’ll be meeting next week here at HMS. Here’s the latest email:

As many of you may know, I have been examining how mRNAs are transported and localized within the cell and how the regulation of mRNA metabolism contributes to gene expression. From data accumulated recently within the “RNA Field”, we know that transcription in eukaryotic cells is very sloppy – that is, a plethora of different…

Here I am, in the lab with one last experiment to go before I leave to feast on a Christmas Eve dinner, so while I wait for that last centrifugation step, I’ll write a quick post about all these great papers on RNA Polymerase II and chromatin remodelling. As I’ve said before, if you want…

Molecular and Cell Biology Carnival #5

Welcome to the December 14, 2008 edition of the Molecular and Cell Biology Carnival. Below the fold, we have a great compilation of entries to share with you.

I just read this fascinating theory that was fully explained in a review that appeared in the latest issue of Cell. This theory connects the origin of cell polarity with aging and it suggests that the centrosome may carry genetic information. Today I’ll focus on the first deep connection polarity and aging. Later this week,…