In addition to my own photos herein, Tom McLaughlin posted a nice slide show of the day at his South Boston News & Record. Despite two trees that snapped and fell in my driveway within six feet of my car in an impressive thunderstorm Friday evening, I drove on Saturday morning to Clover, Virginia, for the dedication of a gravestone that finally marks the final resting place of Henrietta Lacks, a concrete honor, if you will, to recognize the source of one of the most valuable medical tools of the 20th century and today. For those who are not regular readers, Henrietta Lacks was a rural…
Regular readers know that I hold equivocal views of the broad area of dietary supplements, particularly botanical supplements. On one hand, I have seen some great new compounds come from the systematic investigation of herbal and fungal concoctions to the point that 25% of prescription drugs are derived from natural products. On the other hand, some corners of the dietary supplement industry are little more than turn-of-the-last-century snake oil operations, with offenses so egregious that even their own trade associations try to distance themselves from those who adulterate, mislabel, and…
Just a quick post this morning as I am performing my professional responsibility to our nation's health research agency. In yesterday's issue of USA Today (which I only read on the iPhone app or when staying at a hotel that gives it to us free), Donna Leinwand wrote about a currently legal substitute for marijuana called by various names such as K2, Spice, Black Mamba. Nearly a dozen states and several cities are banning or debating bans on K2 -- a packet of herbs coated with a synthetic chemical that mimics a marijuana high when it's smoked -- amid fears that its use is spreading among young…
Men. Check. White. Check. Grey. Mostly. That dude must use color. Beards. Only two. Maybe three. Aw, hell, Church's makes up for the rest. Article here. Ed Yong (Asian-British, man, young, dark hair, no beard) also lists a great wrap-up of the week's commentary on the work.
The leadership team and all the staff here at Terra Sigillata world headquarters was taken aback yesterday when reports surfaced about the appearance of tar balls on the beach at Fort Zachary Taylor State Park and Bahia Honda State Park, the closest long beach to Key West, Florida. A Coast Guard marine laboratory in Connecticut is currently examining the content of the tar balls to determine if they are indeed from, as feared, the BP Deepwater Horizon well. (Someone in the field has to help me out here but I believe there are an awful lot of LC/tandem mass spectrometers at Florida's…
Dichloroacetate or DCA is a small molecule that has been in the press over the last four years due to its potential to inhibit aerobic glycolysis in cancer cells. The cells from each of us usually produce energy in the form of ATP from a variety of nutrient sources plus oxygen using a very efficient process called oxidative phosphorylation. However, when oxygen is partly depleted, such as in skeletal muscle when exercising strenuously ("going anerobic"), energy is produced from glucose by a far less efficient process called glycolysis. Glycolysis is the most primitive form of cellular…
This is going to be a quick welcome to Deborah Blum (@deborahblum) who has just moved her blog, Speakeasy Science, to ScienceBlogs. Why quick? Because I am only 22 pages away from finishing her latest book, The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York. This engaging tale of the race of science and medicine against chemical poisonings for profit and punishment features the true story of NYC chief medical examiner Charles Norris and toxicologist Alexander Gettler. Of course, the other actors are arsenic, methanol, chloroform, thallium, and radium,…
I did not turn on the computer yesterday (yes, it was glorious) so I missed Mother's Day coverage in our local newspaper. When we returned home, I was happy to see that on the front page of the print copy the dean of Duke School of Medicine, Nancy Andrews, MD, PhD, was featured with her daughter in the lab on their fun Saturdays together. Also cited and pictured in the article was Duke vice dean for research and professor of pharmacology and cancer biology, Sally Kornbluth, PhD, and her daughter. Written by News & Observer science editor Sarah Avery, the article describes how women are…
Let me just say at the outset that I generally pay extra to purchase brand name medications, prescription or over-the-counter (OTC), because of concerns I have about federal oversight of generic drug manufacturers. However. On April 30, McNeil Consumer Products issued a voluntary recall of a litany of children's cold products under the Tylenol, Motrin, Zyrtec and Benadryl brand names. McNeil Consumer Healthcare, Division of McNEIL-PPC, Inc., in consultation with the U.S. Food and Drug Administration (FDA), is voluntarily recalling all lots that have not yet expired of certain over-the-…
Wow. I really don't deserve this but I truly appreciate your concern, advice, and best wishes sent over the last few days following my post on losing, and slowly regaining, my voice. I didn't know anyone was still reading but some of you must have seen my RSS feed pop up under the cobwebs on your reader. What's interesting is that I generally look well in person other than getting winded when walking too fast or going up stairs (yes! I can walk up stairs now! w00t!). And to be honest, the loss of 14 lbs I didn't need has actually made me look a little more fit. I've still got a long way to go…
. . .because my voice has also been absent from the offline world. Yes, the final gift to me from LungMutiny2010 is a case of inhaled corticosteroid dysphonia - and another opportunity to cultivate compassion for those with chronic illnesses and permanent loss of physiological functioning. Here's a recap: After a three month battle with pneumonia, I returned to the university as much as I could about six weeks ago. I say "as much as I could" because, once again, I was amazed by how little my body would let me do after being confined to bed for ten weeks. Some days I'd just be doing great and…
So you ran any number of 5K charity races yesterday or went on the Piedmont Farm Tour. But it's a rainy Sunday in the Southeast and you're wondering what to do with a house full of cooped-up kids, especially if it's too soggy to do day two of the farm tour. Let me suggest that you get to Durham, NC, to MakerFaire:NC. Maker Faire is an annual event organized by the people who bring us MAKE Magazine. Maker Faire:NC is a fully sanctioned event but is being planned and coordinated by Raleigh/Durham locals. Our goal is to bring together Makers, Crafters, Inventors, Evil Geniuses, Scientists,…
KFC and Komen? BucketsfortheCure.com? Why don't they just put a pink ribbon on a pack of cigarettes?
The 101st Annual Meeting of my primary professional society, the American Association for Cancer Research (AACR), convened in Washington, DC, on Saturday and will run through Wednesday, April 21. The theme for this year's meeting is "Conquering Cancer Through Discovery Research," and focuses strongly on the translation of discoveries into cancer treatments. Although the Eyjafjallajökull volcanic dust cloud has delayed many European participants, over 17,000 attendees are expected at the Washington Convention Center where over 6,300 presentations are to be given. AACR was founded in 1907 by 11…
I've often remarked that the beauty of this blog is that more people read here every day than I would reach in even the largest class I teach. Moreover, far more people read this blog than will ever read my peer-reviewed scientific publications. And that's even considering that we have very modest traffic numbers here for ScienceBlogs.com. Of course, Terra Sig readers are very discriminating - and good-looking, erudite, and probably even smell good, too. This morning, my Twitter feed brought me a post from the blog, University of Venus, as referred to me by HASTAC Director of New Media…
Down on the left sidebar you'll see a little gizmo for SiteMeter, a service that measures one's blog traffic and gives all sorts of tidbits about how readers got to the blog and a very general idea of where they are coming from. Most bloggers pay attention to the numbers of visitors but I have always been more interested in how readers get here and what posts they are reading. One value of SiteMeter is to keep tabs on search terms that bring people here to learn of breaking stories. So, when I saw a bunch of hits starting yesterday with search terms like "hydrogen sulfide," I feared the…
If you've never heard of Mark Fiore, you should. And will. Mark Fiore of the San Francisco Chronicle was recognized today with the 2010 Pulitzer Prize for Editorial Cartooning. For a distinguished cartoon or portfolio of cartoons characterized by originality, editorial effectiveness, quality of drawing and pictorial effect, in print or online or both, Ten thousand dollars ($10,000). Awarded to Mark Fiore, self syndicated, for his animated cartoons appearing on SFGate.com, the San Francisco Chronicle Web site, where his biting wit, extensive research and ability to distill complex issues set a…
Last Monday marked 17 years since Eric Young led off the first Colorado Rockies baseball game with a home run that triggered a collective, mile-high orgasm for the 80,227 spectators gathered in the old Denver football stadium. The advent of the expansion Rockies also launched a Pharmboy laboratory birthday celebration week tradition marked by two days off: one for a lab ski day in the high country followed later in the week with a Rockies game and the finest handcrafted ale offered by Denver's Wynkoop Brewery. I was reminded of this by my Twitter buddy, Mike Smith (@M1k303) who taunted me a…
Last July we wrote about the 40th anniversary of the Apollo 11 moon landing and spoke of Buzz Aldrin's autobiography about his battle with alcoholism in the years following. The post drew a comment from a reader who I've renamed "Anon." Thank you so much for this post. I am a recovering drug addict and am in the process of applying to graduate programs. I have a stellar GPA, have assisted as an undergraduate TA, and have been engaged in research for over a year. I also have felony and was homeless for 3 years. I don't hide my recovery from people once I know them, but I sometimes, especially…
Today at the University of California at Los Angeles, a rally is planned to raise awareness about the value of responsible animal research and to denounce acts of terrorism toward animal researchers and their families. The highlight of the Pro-Test rally will be the presentation to legislators and the media a petition with nearly 12,000 signatures of scientists who support the use of animals in research. The rally and the petition drive is a joint effort of Americans for Medical Progress, Pro-Test for Science, and Speaking of Research. I stand together with my colleagues who conduct animal…