Real disease "detectives" use evolutionary biology

I wrote recently how evolution and phylogenetic analysis of HIV isolates has provided evidence that the progenitor to HIV jumped into humans in Cameroon or a nearby area. Obviously it's a topic that's interesting to me, but may seem a bit esoteric to some. RPM over at Evolgen has a new post showing another application of phylogenetic analysis to HIV that may be of interest to readers here, where infectious disease epidemiology meets CSI.

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I'm still working on finishing up 3 manuscripts (one book, 2 journal articles) so I've not blogged quite as much this week as I generally do. Next week I should be back up to speed, and have a few topics in the queue that I want to get to. Luckily for you, though, John Hawks has a pair of…
Some infectious agents, it seems, have been with us since the rise of humanity. Bacteria like E. coli or salmonella don't appear to have one moment enshrined in history where they first appeared on the scene. They've probably long been with us, causing disease sporadically but not spectacularly…
It can't be said often enough that "nothing in biology makes sense except in the light of evolution." Moving from physical characteristics--color, bone shape, the form of bacterial cells--to genetic characteristics in order to classify organisms--and infer phylogenies--was a giant advance.…
As PZ mentioned, today would be Charles Darwin's 197th birthday. To celebrate, Mike over at The Questionable Authority is putting together a mini-carnival of posts on evolution. Specifically, he asked how those of us who are scientists use evolutionary theory in our work. Personally, I'm a bit…

Hi Tara,

Thanks for your comment. Katherine was comforting me that at least some of the 2 million that I can't get a date with are underage or very elderly.

Anyway, I was reading this bit about the HIV Cameroon story that really sold me on forensic epidemiology. They were saying they found an single polymorphism that allows the change to humans from monkeys, and it changed back when they put it back into monkeys. It struck me as a very elegant way to find therapeutic targets.

It puts this whole business in a frame of less than esoteric significance.