Life Lines

Cure to fear of cats discovered

…for rodents and men at least.

A team of researchers at UC Berkeley have discovered that mice infected with the parasite Toxoplasma gondii lose their innate fear of cats, even months after the infection is cleared. In fact, infected mice were mildly attracted to the odor of cats. This side effect likely evolved because the parasite can only sexually reproduce in a cat’s gut necessitating ingestion of the parasite. Incidentally, other researchers have described the same side effects in rats and men (but not women). The findings suggest that the parasitic infection causes permanent changes in the brain.

Toxoplasma gondii is a single-celled organism that causes the infection toxoplasmosis, considered by the CDC to be the leading cause of  foodborne illness-induced death. In humans Toxoplasma infection is also associated with behavioral changes and the development of schizophrenia in some people. In fact, studies have suggested that people with schizophrenia are more likely to have at one time been infected with the parasite compared to the general population.

The behavioral effects of the parasite have been attributed to microscopic cysts that form in the brain of infected individuals leading to increased production of the neurotransmitter dopamine. However, since the behavioral effects in the current study were found to persist even after the infection was considered cleared, the behavioral changes may not be due to cyst-induced dopamine production, but rather to some form of “re-wiring” in the brain.

It should be noted that other researchers suggest mice may not be the best model for studying Toxoplasma infections. Although an advantage to mice is that there are genetic tools available for studies with mice that are not available with other species. Some researchers also question whether the parasite causes schizophrenia in humans or whether people with schizophrenia are simply more likely to contract the parasite.

 

kat-and-mouse

 

Sources:

Ingram WM, Goodrich LM, Robey EA, and Eisen MB. Mice Infected with Low-Virulence Strains of Toxoplasma gondii Lose Their Innate Aversion to Cat Urine, Even after Extensive Parasite Clearance. PLoS ONE 8, e75246 (2013).

Nature News

Comments

  1. #1 GregH
    September 28, 2013

    Thanks for that very clear summary. If the link between schizophrenia and T. gondii exposure is real, is schizophrenia then a disease of poverty?