Molecule of the Day

Awhile back, I discussed dicyclohexylcarbodiimide: a condensing agent that helps turn biological monomers (like amino acids) into polymers (like proteins). People use it a lot on peptide synthesizers for this purpose, where the peptides are made in organic solvents. A related compound, EDAC, works in water:


EDAC works just like dicyclohexylcarbodiimide, but in water. People have used it to, for example, condense short pieces of DNA into longer ones.

I’ve heard it’s a sensitizer (allergen) like DCC, but I’m not sure if it’s quite as bad (no vapor pressure, anyway).


  1. #1 vijaypalreddy
    March 3, 2009

    I woluld like to use this reagent plz let me know the price of the reagent
    I want to use this to make an a Primary amide is it is possible ?

  2. #2 Chemoptoplex
    March 3, 2009

    And you can remove the urea from your product with a simple acid wash.

  3. #3 gyg3s
    March 31, 2009

    I seem to remember reading somewhere that one of the dangers of using EDAC was that exposure to it could lead to depression.

  4. #4 Mendel Potok
    September 9, 2010

    Interesting, i didn’t know this had an application in DNA, I’ll have to check this out.

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