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terrasig | January 13, 2009I just started receiving a bunch of Google referral hits from readers searching for a story about the US Federal Trade Commission apparently taking regulatory action against a church that is selling supplements claimed to exhibit anti-cancer activities.
The article in question, "Tyrannical FTC Threatens Christian Church with Imprisonment for Selling Dietary Supplements," was written by a gentleman named Mike Adams, an editor at NaturalNews.com. I'm not exactly certain at this point what the specific FTC actions are today since the article is rife with rantings and rhetoric:
The FTC has…
terrasig | December 30, 2008I see you - I've been there.
You're sitting in the lab the day before New Year's Eve looking at what you've done over the last year - or last six years - and thinking about how you're ever going to turn this postdoc or extended grad school period into some gainful career. The economy is for hell no matter where you live and you're wondering if this is all worth it.
Well, as I've said before, don't limit your options until you explore them. The US drug, medical device, food, cosmetic regulatory and safety agency, the Food and Drug Administration (FDA), can provide a really satisfying…
terrasig | August 28, 2008A couple of colleagues turned me on the other morning to a press release by researchers at the University of Warwick who recently published in PNAS that their data apparently overturns the Meyer-Overton Rule regarding solubility of a compound in olive oil and its propensity for crossing biological membranes. I'm having trouble understanding exactly why their conclusions are earth-shattering.
At the turn of the last century, Meyer (1899) and Overton (1901) independently conducted experiments to demonstrate that the longer the carbon chain of a molecule, the better it partitioned into olive…
terrasig | August 13, 2008Most people know of methadone as a long-term substitution therapy for people addicted to heroin, morphine, or other similar drugs called opiates or opioids. A good, free full-text description of methadone maintenance therapy (MMT) can be found in the 15 June 2001 issue of American Family Physician.
Now, in the 1 August 2008 issue of Cancer Research, Claudia Friesen and colleagues at the University of Ulm report that methadone can kill leukemia cells in culture and reverse acquired resistance to other drugs like doxorubicin (Adriamycin). Press reports to this effect appeared at the beginning…
terrasig | June 4, 2008This whole "cosmeceutical" thing probably shouldn't be in "Medicine & Health" but we did call your attention to today's news item back on 27 July 2007: Drug maker Allergan announced at a stock analyst's meeting this afternoon that it is filing a New Drug Application (NDA) for a cosmetic form of its anti-glaucoma drug bimatoprost (Lumigan®) as a result of it side effect in increasing the number and thickness of eyelashes.
Allergan (nyse: AGN) has completed its clinical trial program demonstrating that its patented formulation of bimatoprost, when applied directly to the base of the…
terrasig | May 31, 2008Our quick post yesterday cited Jonathan Alter's Newsweek essay this week on the sad state of cancer research funding in the context of Hamilton Jordan's recent death and Ted Kennedy's recent glioblastoma diagnosis. Like many areas of US federal research funding, cancer research support has been flat under the Bush administration and, in fact, declined in real dollars since 2004.
But when one hears a federally-funded researcher like me whining about this situation, one might think I am solely acting in a self-serving fashion, caring only about the preservation of my career and that of my…
When medical experimental therapeutics gets co-opted as complementary and alternative medicine (CAM)
terrasig | May 8, 2008Sorry to get to this so late but I wanted to weigh on an excellent post from my cancer blogging colleague, Orac, the other day on the investigation of CAM therapies in cancer. The post covers a lot of ground, as expected from any of Orac's exhaustive missives, but I wanted to focus on the comparison and contracts between NIH's National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Cancer Complementary and Alternative Medicine within the National Cancer Institute (NCI-OCCAM).
I am on record as a strong critic of NCCAM but a supporter of NCI's OCCAM in that the…
terrasig | April 28, 2008Well, not only am I weaseling out of posting original content today but I'm going to direct you to an excellent repost by Bora Zivkovic at A Blog Around the Clock.
I am often asked why plants expend the bioenergetic capital to synthesize secondary metabolites. In his post, Bora notes that the synthesis of capsaicin by hot peppers results in selective avoidance by mammals but an interesting co-evolutionary relationship with thrashers.
And in other news, mosey on over to the newest member of the ScienceBlogs community, the superb ERV blog written by Abbie Smith, a graduate student in Middle…
terrasig | April 12, 2008". . .you got marijuana in my lead."
Two great tastes that do not go great together (with apologies).
[Welcome Fark.com readers on 12 Oct 2008 - I comment on the recent story here and you can read our other posts on drugs of abuse here. Thanks for stopping by - APB]
A concise but fascinating medical detective story appears in the letters of this week's (10 Apr 2008) issue of the New England Journal of Medicine (free full text at the time of this posting.).
An astute group of physicians at Leipzig Hospital in Germany noted a local surge of young people presenting with classic symptoms of…
terrasig | April 4, 2008Actinomycin D was the first antitumor antibiotic isolated from Streptomyces parvallus cultures by the lab of 1952 Nobel laureate, Dr Selman Waksman, at Rutgers University. However, it took a young Chinese physician and the confidence in her by a future US Surgeon General for this natural product drug to positively impact the lives of children with cancer.
An unusually engaging Boston Globe obituary by Gloria Negri caught my attention this week that announced the death of pediatric oncology pioneer, Charlotte Tan (Hsu), MD, of pneumonia on 1 April in Brookline, MA. Dr Tan's 1959 paper in…
terrasig | March 30, 2008In attempting to re-engage my academic brain stem, I've been doing a little continuing education the last couple of weeks at various forums hosted by the University-That-Tobacco-Built. Last week I had the pleasure of attending a forum of the Duke student organization, Women in Science and Engineering (WiSE), that featured four academic leaders (who were women) and Bora Zivkovic discussing non-bench science careers.
One of the panelists was an old colleague, Dr Rochelle (Shelly) Schwartz-Bloom, an award-winning neuropharmacologist and educator in the Duke Department of Pharmacology &…
terrasig | March 29, 2008A paper in last month's issue of Nature Reviews Drug Discovery reported that US drug approvals during 2007 were the lowest number since 1983. (17 new molecular entities and 2 biologicals; see this figure for 1996-2007 data.) The review cites increased regulatory action as a factor in this reduction, especially following high-profile post-marketing safety issues with blockbuster drugs like Vioxx or Avandia. But other commentators have noted other problems such as the science of drug discovery in pharma being overridden by managers or the reluctance to develop agents for diseases that afflict…
terrasig | March 20, 2008The safety and effectiveness of medicines and other health products is dependent upon their proper use, particularly the proper route of administration. There are reasons why products are labeled as "for topical use only" or "do not swallow" - two recent warnings from the US FDA illustrate these issues.
Allergic Reactions with Use/Misuse of Denture Cleansers
The FDA recently announced reports of one death and 72 other adverse reactions in individuals who ingested denture cleansers meant to be used in a container with one's dentures removed. A crucial oxidizing agent, salts of persulfate,…
terrasig | March 1, 2008DrugMonkey just had an interesting post about the potential influence of cocaine use trends following the 1986 death of Maryland college basketball player, Len Bias, just days after his being selected in the NBA draft by the Boston Celtics. DM's post and the ensuing discussion got me thinking tonight about a variety of issues in substance abuse, realistic assessment of risk and, ultimately, parenting.
In the comments, I mentioned that Heath Ledger's recent death might be a trigger for pop culture to pay more attention to the risks of recreational use of prescription and over-the-counter…
terrasig | February 6, 2008I'll leave my neuropharmacology and neuroscience colleagues to comment in greater detail on this story (see earlier DrugMonkey post), but this report is just in from AP on Heath Ledger's toxicology report:
The cause of death was "acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam and doxylamine," spokeswoman Ellen Borakove said in a statement.
I haven't seen a copy of the report itself (maybe Smoking Gun will have it soon) but plasma concentrations of each were not noted. However, this was the statement from the family:
In a statement…
terrasig | January 29, 2008. . .that's the message from Dr Bertha Madras, deputy director of the White House Office on National Drug Control Policy, to heroin and morphine users whose lives might be saved in the overdose situation by public distribution of "overdose rescue kits" comprised of a $9.50 nasal spray containing Narcan.
Narcan is the brand name for naloxone, an antagonist (blocker) of these drugs at μ opioid receptors. When an overdose of opioid drugs binds to these receptors in the respiratory control center of a primitive part of our brain, one stops breathing, a situation that pathologists say is "…
terrasig | January 10, 2008This question, posed by Michigan Tech professor Dr Seth W Donahue while hiking in the Sierra Nevada, has led to the discovery of an extremely potent form of parathyroid hormone produced by black bears (Ursus americanus). In an unusual take on my usual topic of natural product therapeutics, Donahue's hope is that the ursine form of the hormone might serve as the basis for novel drugs to treat osteoporosis in humans, hibernating (on the couch) or otherwise.
Dr. Donahue's research on bears has advanced far enough toward a treatment for humans to capture commercial interest. Apjohn Group, a…
terrasig | December 30, 2007In rats, though. But still very interesting.
So says yesterday's New York Times Op-Ed by psychiatrist, Paul Steinberg, entitled, "The Hangover That Lasts." This timely piece follows our discussion on Friday about champagne choices for New Year's Eve, the premier event for binge-drinking.
While I'm not a neuropharmacologist, Steinberg's article piqued my interest because it focuses on the work of Dr Fulton T Crews and his former student Dr Jennifer Obernier (now with the National Academy of Sciences) at the University of North Carolina at Chapel Hill. Dr Crews is director of the UNC Bowles…
terrasig | November 19, 2007As we approach 100,000 visitors since joining ScienceBlogs I am amazed to still be getting 500-700 visits per month at the old home of Terra Sigillata, all without any promotion or new posts. The most-visited of the old posts is the following which appeared originally on 21 February 2006.
Much of humankind's experience with pharmacologically-active natural products has been through the mind-altering effects of plants used in religious ceremonies.
Today [21 Feb 2006], the US Supreme Court upheld a decision to permit a New Mexico sect of a Brazilian religious order to continue using an…
terrasig | November 7, 2007Orac's recent post, A Real Death By Homeopathy, led me to dig through the archives at my old blog and reprint one of my first posts, this one from 6 January 2006. As a natural products researcher, I often see homeopathy associated with herbal medicines, the latter of which has often been the source of beneficial pharmaceuticals. In sharp contrast, homeopathy is based on a faulty 19th century principle that is the direct opposite of dose-response pharmacology and I intended to comment briefly on the distinction, as stimulated by a misleading picture on the cover of one of my favorite print…