We all thought that it was a bit early, but VERY deserved. Also can I add this:
For anyone not in the basic biomedical sciences, the two biggest revolutions in the past 10 years have been RNA interference (RNAi) and fluorescent protein technology. The two techniques allowed us to perform genetics in higher eukaryotes and to visualize proteins over time. When both came on the scene it was truly amazing. People first gossiped about both technologies and the buzz spread fast. Within months everyone was using the technique to probe their field of enquiry further. It was like someone came to Thailand and started selling cellphones to the average citizen who didn’t even own a land line. The next day everyone is text messaging and couldn’t imagine life in any other way. In addition, Ambrose (who could have got it as well) showed that our own cells (well at first worms, but it was true for humans too) make their own substrates for RNAi and use it to regulate the expression of our own genes. Our genome was expanded. Now with the latest bioinformatic info, we are coming to realize that we make many little RNA bits that perform all sorts of functions.
OK now lets see if fluorescent protein technologies gets the Chemistry.
I’ll post a brief history of RNAi later today.
P.S. Fire and Mello got it and everyone expected this, but Rich Jorgensen or Victor Ambrose should have got the third spot. More on this in the next post.