John Ioannidis
oracknows | June 12, 2016Most scientists I know get a chuckle out of the Journal of Irreproducible Results (JIR), a humor journal that often parodies scientific papers. Back in the day, we used to chuckle at articles like "Any Eye for an Eye for an Arm and a Leg: Applied Dysfunctional Measurement" and "A Double Blind Efficacy Trial of Placebos, Extra Strength Placebos and Generic Placebos." (What saddens me is that this is basically what research into so-called “complementary and alternative medicine,” now more frequently referred to as “integrative medicine” boils down to.) Unfortunately, these days, reporting on…
oracknows | April 3, 2016It's no secret that I'm a fan of John Ioannidis. (If you don't believe me, just type Ioannidis' name into the blog search box and see how many posts you find.) Over the last couple of decades, Ioannidis has arguably done more to reveal the shortcomings of the medical research enterprise that undergirds our treatments, revealing the weaknesses in the evidence base and how easily clinical trials can mislead, than any other researcher. Indeed, after reading what is Ioannidis' most famous article, "Why Most Published Research Findings Are False", back in 2005, I was hooked. I even used it for our…
oracknows | February 18, 2015
It often comes as a surprise to proponents of alternative medicine and critics of big pharma that I'm a big fan of John Ioannidis. Evidence of this can easily be found right here on this very blog just by entering Ioannidis' name into the search box. Indeed, my first post about an Ioannidis paper is nearly a decade old now. These posts were about one of Ioannidis' most famous papers, this one published in JAMA and entitled Contradicted and Initially Stronger Effects in Highly Cited Clinical Research. It was a study that suggested that at least 1/3 of highly cited clinical trials may either…
oracknows | January 9, 2013About a year and a half ago, I applied a heapin' helpin' of not-so-Respectful Insolence to a a clueless article about the the "triumph" of New Age medicine. The article channeled the worst fallacies of apologists for alternative medicine. Basically, its whole idea appeared to be that, even if most of "complementary and alternative medicine" (CAM) or "integrative medicine" is quackery (which it most certainly is), it doesn't matter because allegedly it's making patients better because its practitioners take the time to talk to them in a way that most doctors do not. In brief, the article was…