One of the overarching issues, if not the overarching issue that makes so-called "complementary and alternative medicine" (CAM)—or, as it's now more commonly called, "integrative medicine"—so problematic is prior plausibility. It's also one of the most difficult to explain to the lay public, because to someone not trained in science it can sound like not being open-minded. I like to joke about this whole concept by saying that it's good to be open-minded but not so open-minded that your brains fall out. In other words, the main difference between science-based medicine (SBM) and evidence-…