Lactase Persistence
razib | March 2, 2010As you know lactase persistence (LP), which confers the ability to digest lactose sugar as an adult, is an evolutionarily recent development. On the order of 1/3 of the human population exhibits LP, due to a variety of genetic mutations which seem to arise in the cultural background of the domestication of cattle. Some have asked about the possible associations between LP & height & weight before. A new paper in Human Molecular Genetics looks at just that, European lactase persistence genotype shows evidence of association with increase in body mass index:
The global prevalence of…
razib | February 16, 2010Lactase persistence results in the ability to break down the lactose sugar in milk as an adult, lactase being the enzyme which breaks down lactose. If one can not digest that sugar, and still consumes milk, then one exhibits the symptoms of lactose intolerance. Originally diagnosed as a disease it has come to light that 2/3 of the world's population is lactose intolerant, and, that this is probably the ancestral "wild type" (I would be interested if readers could name a mammal which exhibited lactase persistence aside from humans). Lactase persistence is a relatively new trait which emerged…
razib | May 11, 2009Dienekes reports on an abstracts for paper presentations at the ESHG 2009. This was is particularly interesting:
European Lactase Persistence Allele is Associated With Increase in Body Mass Index
J. A. Kettunen et al.
The global prevalence of obesity, usually indexed by body mass index (BMI) cut-offs, has increased significantly in the recent decades, mainly due to positive energy balance. However, the impact of a selection for specific genes cannot be excluded. Here we have tested the association between BMI and one of the best known genetic variants showing strong selective pressure: the…