Normally, these days I greet the month of October with a mixture of anticipation and dread. The anticipation stems from October’s position as Breast Cancer Awareness Month. Now that somehow I’ve managed to have a variety of responsibilities with respect to how breast cancer is managed at our cancer institute, suddenly I find that I’m sometimes called upon to do media appearances, and Breast Cancer Awareness Month is one time we can use to get our message out about breast health and breast cancer detection and treatment, not to mention to highlight for the local media some of the cool research that goes on here. Every year (or so it would seem) the quacks, cranks, and haters of science-based medicine come out of the woodwork to use October as an excuse either to attack “conventional” medicine (particularly anything related to breast cancer), promote quackery, or both.

In 2014, here we go again.

It would appear that in the wake of their ridiculous #CDCwhistleblower campaign, antivaccinationists have decided to infest Twitter in a big way. This time around, they appear to have foolishly decided once again to try to co-opt with Breast Cancer Awareness Month by trying to co-opt October as “Vaccine Injury Awareness Month” with their usual pseudoscience, persecution complex. It’s something that appears to have started in 2010 and has been resurrected every year since then. This year, antivaccinationists are trying to deluge Twitter with ridiculous hashtags such as #CDCwhistleblower, #hearthiswell, and #VaxTruth. For example:

vaccineawareness

And:

vaccineaware

Unfortunately, it’s just as ridiculous now as it was then. Still, it might be fun to tweak antivaccinationists during their Twitter tempest in a teacup with some actual science. Or not. Either way, I’m guessing this latest Twitter tantrum will work about as well as previous antivaccine Twitter tantrums, as in not at all.

Comments

  1. #1 Narad
    October 26, 2014

    ATTENTION: UK dolts (you know who you are, Denice Walter)

    Holy Christ, you’re stupid.

  2. #2 Narad
    October 26, 2014

    please direct yourselves to newly published #580, I wouldn’t want you to miss it

    I certainly wouldn’t want to miss your explanation of what this has to with your actual #580, because it has to be even more comical than the obvious one.

  3. #3 ChrisP
    October 26, 2014

    The ignorance of the various incarnations of Timmeh is astonishing. But that may be deliberate. He may want to have it appear that Keith Bell is not the most ignorant commenter on this thread.

    He might have to work a bit harder though.

  4. #4 Narad
    October 26, 2014

    How about impotence related to constipation? Any insights?

    “Oh my [G-d] Almighty! Someone has sent me a BOWEL MOVEMENT!”

  5. #5 Narad
    October 26, 2014

    The ignorance of the various incarnations of Timmeh is astonishing.

    Oh, wait, “Timmeh” was Tim? (*plonk*)

    Thanks.

  6. #6 Denice Walter
    October 26, 2014

    @ Narad:

    At least he hasn’t figured out that we’re in Hobart…
    Oooops!

  7. #7 herr doktor bimler
    October 26, 2014

    It’s been known anorexia is high in archaea

    I had not previously heard of archaeobacteria refusing to eat.

  8. #8 Keith Bell
    October 26, 2014

    “So, to my question, how does vitamin D3 help maintain a healthy immune system?”

    It’s about activating innate immunity, balancing flora which interact with the immune system. Vitamin D3 is required for intracellular calcium absorption which then activates B and T cells and macrophages. Intracellular calcium also required for bone mineralization.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256336/

  9. #9 Robertapate
    Washington
    October 26, 2014
  10. #10 Narad
    October 26, 2014

    At least he hasn’t figured out that we’re in Hobart…

    Lady, you must be psychic. I happen to know, via a deep, dark corner of the Internet, a case of someone who eventually reached such a low signal-to-noise ratio as to invite no further comment other than speculation upon his life in Hobart. Indiana.

  11. #11 Keith Bell
    October 26, 2014

    Speaking of inbred Germans of Hobart, it’s interesting to note both large-headed, autistic geniuses suffering indigestion, Darwin and Einstein, married their cousins:
    http://io9.com/5863666/why-inbreeding-really-isnt-as-bad-as-you-think-it-is

    Inbreeding along with pig farming may be factors for Utah leading the USA in autism, 2012. Inbred Iceland’s skyrocketing autism rate has increased seven-fold since first measured in 1977.

    The remainder of this thread through 1,000 comments will be focused on inbreeding; more conducive to this close knit group. Denice, please begin the discussion about Charles II of Spain and his large tongue.

  12. #12 Narad
    October 26, 2014

    It’s about activating innate immunity, balancing flora which interact with the immune system. Vitamin D3 is required for intracellular calcium absorption which then activates B and T cells and macrophages. Intracellular calcium also required for bone mineralization.

    There’s a shocker.

    Mr. Bellend, are your gut microbiota so out of whack that you thought people couldn’t actually read this? Show me even one successful, direct exercise in connect-the-dots from Youssef et al. that gets you to… well, fυcking anyplace.

  13. #13 Narad
    October 27, 2014

    Inbreeding along with pig farming may be factors for Utah leading the USA in autism, 2012.

    Keith, I will be fascinated with your reconciling of “2012” with “2014.” Please be sure to include state spending on early diagnosis as a covariate in addition to pig- and sibling-fυcking.

  14. #14 herr doktor bimler
    October 27, 2014

    You’re all acting like a family of laughing, yawning hyenas

    The old observation about poker comes to mind. If everyone in the room is laughing, but you haven’t worked out who the clown is, it’s probably you.

  15. #15 Shay
    Hebrews 13:8
    October 27, 2014

    I’m gone for two days and the Bell is still ringing. What a glutton for punishment.

  16. #16 herr doktor bimler
    October 27, 2014

    Inbred Iceland’s skyrocketing autism rate has increased seven-fold since first measured in 1977.
    This would make more sense if the rate of consanguinous marriage in Iceland had also increased seven-fold since 1977.

    Matt Carey noted that the proportion of autism diagnoses increased within a specific age cohort:

    In 2005, the kids in this study were 7-11 years old, and over the next few years the fraction of those kids identified as autistic doubled.

    — demonstrating how reported rates are dominated by shifting diagnostic criteria and closer scrutiny.

  17. #17 Narad
    October 27, 2014

    demonstrating how reported rates are dominated by shifting diagnostic criteria and closer scrutiny

    Not until Große Sperma says so, of course. I’m sure that his fictitious Florida corporation has a laboratory “team” at the ready to screen Finnish samples, though.

  18. #18 Narad
    October 27, 2014

    I have, however, omitted one eminently relevant historical artifact:

    Keith, could you provide a gut–brain analysis of the lone novel by Richard Fariña? I mean, it’s all right out there, with salad forks and everything.

  19. #19 Julian Frost
    Gauteng East Rand
    October 27, 2014

    Keith:

    Regarding rickets, I fear you’ve both missed the main point: rickets is a matter of microbial predisposition as children are born compromised from the wombs of compromised mothers likely suffering gestational diabetes. Children don’t simply acquire rickets after birth, they’re born with imbalanced flora leading to rickets.

    Citation needed, or I’m going to have to agree with Johnny @ #589 that you’re a crank.

  20. #20 herr doktor bimler
    October 27, 2014

    factors for Utah leading the USA in autism, 2012.
    Keith, I will be fascinated with your reconciling of “2012” with “2014.”

    I note for the record that both reports collate a snapshot of diagnoses from four years previously; that is, there are snapshots from 2008 (for 14 states) and 2010 (for 11 states). It is nugatory to write of ” Utah leading the USA in autism, 2012″ — or even of Utah leading 11 states! — for those data have not been published yet.

  21. #21 herr doktor bimler
    October 27, 2014

    Keith, could you provide a gut–brain analysis of the lone novel by Richard Fariña?

    You mean Gnossos’ constipation, and his flatmates’ determination to have the resultant epic turd cast in bronze?
    The Whackyweedia informs me that there was a 1970 movie version of BDSLILLUTM. A remake would be nice.

  22. #22 Helianthus
    France
    October 27, 2014

    @ Shay

    I’m gone for two days and the Bell is still ringing.

    To paraphrase a French website proposing entertaining riddles:

    Il y a ceux qui raisonnent, et il y a ceux qui résonnent.

  23. #23 Krebiozen
    October 27, 2014

    Keith,

    Regarding rickets, I fear you’ve both missed the main point:

    Your main (only) point seems clear to me, but you haven’t provided any evidence at all to support it. I simply don’t understand why you have come to your beliefs about gut flora and rickets. The only real reason I’m bothering to engage you is that I’m curious about this odd fixation you seem to have acquired.

    rickets is a matter of microbial predisposition as children are born compromised from the wombs of compromised mothers likely suffering gestational diabetes. Children don’t simply acquire rickets after birth, they’re born with imbalanced flora leading to rickets.

    Some children are born with vitamin D deficiency because their mothers are vitamin D deficient. Why would anyone think there is a connection with gut flora? Or gestational diabetes?

    Perhaps you are unfamiliar with the history of rickets, the discovery of successful treatments, and its causes. Here’s an interesting article on the subject. Some apposite passages:

    As early as 1822 Sniadecki identified the importance of sun exposure for preventing growth retardation and skeletal deformities associated with rickets noting that children living in the inner city of Warsaw had a high incidence of rickets whereas children living in adjacent rural areas did not. This was followed by the insightful observations in 1889 by Palm that children living in London and Glasgow were plagued with rickets while children who lived in squalor in Asia and India were free of the disease. He recommended that children from the inner cities should be exposed to sunlight and encouraged sunbathing as a preventive and treatment strategy. However, the medical community found it inconceivable that skin exposure to sunlight could have any beneficial effect for bone health.

    In 1919, Huldschinsky exposed children to a mercury arc lamp and demonstrated radiologic healing of rickets. He promoted the use of ultraviolet irradiation as an infallible cure for rickets. Pharmacies in the United States and Europe sold ultraviolet lamps to parents so that they could expose their children to the anthracitic ultraviolet radiation. In 1921, Hess and Unger exposed several children who had rickets to sunlight on the roof of a New York City hospital and demonstrated dramatic improvement in their rickets. […]

    Within a few years after this process of fortifying milk with vitamin D was implemented in the 1930s, rickets was eradicated as a health problem. This was implemented in the 1930s along with widespread use of cod liver oil, within a few years, eradicating rickets as a public health problem.

    How is any of this consistent with your gut dysbiosis theory of rickets? Why would rural Polish children and “children who lived in squalor in Asia and India” have healthy gut flora while those living in cities did not? Do sunlight and cod liver oil somehow produce healthy gut flora?

    Here’s another paper, from India, that throws more light on the causes of rickets in South Asian people. Some more apposite passages:

    The most important misconception about vitamin D-deficiency osteomalacia especially in Asians living in UK is that it results due to their skin pigmentation, vegetarian diets, and consumption of unleavened chapatis made out of high extraction wheat flour rich in fibre and phytate contents.

    In our studies we have performed separate measurements of serum 25(OH)D3 (skin synthesized vitamin D) and 25(OH)D2 (dietary vitamin D) and demonstrated that the contribution of 25(OH)D2 to total circulating 25(OH)D in normal women of child bearing age was negligible, less than 8 per cent and over 92 per cent of serum 25(OH)D was endogenously synthesized, following exposure to sunlight (UVB 290-315nm) and confirmed the marginal or the negligible role of dietary vitamin D.

    All women, house bound, living in crowded localities and dark alleys, with covered-up style of clothing and purdah and thus, deprived, of sun exposure, are at the highest risk of developing vitamin D-deficiency osteomalacia. Thus, the inadequate vitamin D synthesis in the skin due to lack of exposure to sunlight (UVR) is the fundamental abnormality which plays the pivotal role in the aetiopathogenesis of vitamin D-deficiency osteomalacia. This emerging fact has been strongly supported by the cure of vitamin D-deficiency osteomalacia, only by ultraviolet radiation from mercury vapor quartz lamp and the exposure to sunlight in several studies.

    So lack of sunshine, rather than diet (or gut dysbiosis), appears to be the main driver of rickets.

    If that were not enough to demonstrate the causes of rickets, there is also this:

    Vitamin D-deficiency osteomalacia as defined and occurred in our patients has shown selective geographic distribution. The geographic prevalence of osteomalacia showed that the women residing in the northern parts of India were heavily affected then those living south to Mumbai and Kolkota in the south to western and eastern States of India.

    This difference in the incidence of osteomalacia is due to North-South gradient of the solar ultraviolet radiations (UVR-B 219-315 nm) which are essential for the endogenous cutaneous synthesis of vitamin D. Synthesis of vitamin D in the skin is reduced by residence at northern latitudes distant from the equator and atmospheric pollution.

    It’s worth noting that Bangladesh is north of India, so it gets less sunshine, and it is an entirely Muslim country (in India Muslims are found mainly in the north) , so people tend to be covered up with little sun exposure to bare skin. This (along with malnutrition and contaminated water) is the most likely explanation for the high rate of rickets in Bangladesh, rather than any putative differences in gut flora. Why would gut flora show north-south variation like this?

  24. #24 Krebiozen
    October 27, 2014

    I hope the mangled blockquotes are clear enough, sorry.

  25. #25 herr doktor bimler
    October 27, 2014

    We’ve swapped Kerbiozen’s [/blockquote] tag for a nested indentation! Let’s see if he notices!

  26. #26 squirrelelite
    October 27, 2014

    @Tim,

    The drug is leviteracetam, commonly known as Keppra or Kepra. http://www.rxlist.com/keppra-drug.htm

    I’ve been on medication to control seizures for almost 40 years now. This is the fifth medication I’ve used and has the best results with the fewest side effects of all. I wouldn’t switch to a different medicine without an excellent reason and a very careful consultation with my neurologist.

  27. #27 squirrelelite
    October 27, 2014

    @Robertapate,

    Thanks for the link. It’s a good basic starter reference, although it doesn’t have much specific to say about the role in immune health.

    The link about the vitamin D trial in children was interesting
    http://www.ncbi.nlm.nih.gov/pubmed/20219962
    although the confidence interval for the relative risk reduction (0.34 – 0.99) was barely significant.

  28. #28 Denice Walter
    October 27, 2014

    @ Narad:

    I’m not psychic. -btw- wrong Hobart.

    My eponymous ‘friend’ lives in Tasmania: I hope she suffers no harassment because of my activities.

    BUT it appears our visitor has discovered the deepest, darkest secret of RI’s minions…..
    INCEST!
    Right. We’re all cousins.

  29. #29 Timmeh
    October 27, 2014

    If two vortices orbit one another due to the Fujiwhara Effect, how do two dominatrices in close proximity interact?

    http://eusa-riddled.blogspot.co.nz/2012/11/inter-disciplinary-research-madame.html

    Interesting query.

    Quasi-coherent counterspin enthalpic superstrap swap?

  30. #30 Dr. Johansen
    im from sveedun.. You know, punta punta...
    October 28, 2014

    establish some requirement to demonstrate efficacy and safety for doses significantly above the RDA’s.

    I could live with that. A small part of it. Idk why this value, 6667%, is on all the vitamins from the single thiamine and riboflavin to the Malwart** b-complex ones. I just mix the T and R up in a bucket and make 10 doses outta a couple caps.
    ————————————-

    **Malwart — Your one-stop, stupershoppe*** for cheap, plastic multivitamins.

    ***NOT to be confused with The Vitamin Shoppe (unless I’m talking about their dysfunctional website) which every now and again have knowledgable employees who can direct one right past the rows of RDI and right to the monomethionate and other obscure woo of which you seek.

  31. #31 Shay
    In the land where keyboards have no accent circonflex
    October 28, 2014

    @ Helianthus — c’est drole.

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