Here is a report on some developments on the hypothesis that humans are very well evolved to run in the heat. A physical anthropologist told me that while cold adapted peoples can acclimate to tropical conditions, heat adapted peoples are not as good at the reverse. That suggested to me that as a tropical species we have deep and extremely powerful adaptations which allow us to tolerate heat, and these adaptations might have other uses that remained advantageous once we moved north into Eurasia.
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The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation:
There is a discussion on the internet about Junk DNA, that includes a discussion at Sandwalk (Larry Moran's blog) ... I made a comment there about genome size that was responded to by T.R. Gregory. I started to write my response in Larry's Little Box, but realized that it would not fit.
John Hawks, along with Gene Expression regular Greg Cochran, has published a paper (PDF) on adaptive introgression in human evolution.