Geneic Future has a review & mulling over of implications of a new paper, High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation. Well worth the read.
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One of the major challenges of the personal genomic era will be knowing exactly which (if any) of the millions of genetic variants present in your genome are likely to actually have an impact on your health. Such predictions are particularly problematic for regulatory variants - genetic changes…
Willer et al. (2008). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Nature Genetics DOI: 10.1038/ng.287
Thorleifsson et al. (2008). Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity…
Jeffrey Perkel at Biotechnically Speaking has a great overview of a recent paper in Nature Methods (see also coverage at GenomeWeb).
The study in question used second-generation sequencing (with the ABI SOLiD system) to peer inside a single cell isolated from a mouse embryo. By sequencing the…
Over at Gene Expression Classic p-ter points to an interesting paper, Genetic Architecture of Tameness in a Rat Model of Animal Domestication:
A common feature of domestic animals is tameness - i.e. they tolerate and are unafraid of human presence and handling. To gain insight into the genetic…