Aging/Gerontology
neurotopia | November 15, 2007Abel over at Terra Sigillata got is writ in a tinger over bad grammar and was concerned that Alzheimer's Disease had been tied to risky sexual behavior. His conclusion was that he got a poorly worded email notice about two separate problems that were linked inappropriately by a semicolon. So everything's fine, all clear, right? He's free to engage in risky sexual behavior without fear of getting Alzheimer's Disease (AD) later in life!
That's not entirely true.
We've known that inflammation plays a huge role in the Alzheimer's disease process. Unfortunately, inflammation is caused by a…
neurotopia | August 29, 2007Finally we get some data on changes in AD pathology with statin use! Statins are taken for lowering cholesterol, but they have other beneficial effects such as modulating inflammatory responses. Thus, they could prove beneficial in the treatment of AD given the disease has a significant inflammatory component.
According to the press release
The two changes in the brain that are considered the most definitive hallmarks of Alzheimer's are brain "plaques" and "tangles." After controlling for variables including age at death, gender, and strokes in the brain, the researchers found…
neurotopia | July 18, 2007Yes, that title is a bit ostentatious. But the foods we eat contain many compounds that can be beneficial to brain health. One strategy for optimizing our brains for long-term peak performance is to identify these compounds and discover how they are beneficial. Head-healthy chemicals have previously been isolated from curries and spices before, and it looks like we've found another curcuminoid, bisdemethoxycurcumin, which may be useful in combating Alzheimer's Disease:
Researchers have isolated bisdemethoxycurcumin, the active ingredient of curcuminoids -- a natural substance found in…
neurotopia | July 9, 2007I recently posted three "Basics"-style blurbs about menopause and hormone therapy (HT). If you missed it, they are here, here, and here. The field has gone through a lot of upheaval since the WHI studies in 2002, and I would just like to share my thoughts on how to approach where we stand now. These are the sorts of questions and considerations that researchers and health care professionals need to keep in mind when they evaluate HT. After the reference-heavy previous posts this one is going to just be my thoughts, and very off-the-cuff at that.
We, as humans, have a tendency to put…
neurotopia | July 5, 2007This is the third part in an overview of menopause and hormone therapy. Parts one and two are here and here. This time around I describe changes in cognitive and behavioral profiles for women and animal models of menopause. I may decide to expand on a handful of studies at a later date, but for now I wanted to provide a very brief overview of human studies, problems inherent to human studies, and animal studies. I think the next part of this series will focus on the quality of our animal models and what they have to tell us. But for now, anyone who is interested in these issues knows where…
neurotopia | July 4, 2007This is the second of a series that examines menopause, hormone therapy, and consequences of each. Today's installment looks at the makeup of common hormones on the market, physiological consequences of hormone loss and replacement, and the Women's Health Initiative (WHI) studies. A slight emphasis is placed on Alzheimer's Disease as a segway to the next installments, which will focus on cognitive and neurobiological consequences of menopause and hormone therapy.
Components of Common Hormone Therapies
17-beta estradiol (E2), the primary circulating estrogen during reproductive years, was…
neurotopia | June 13, 2007I thought I'd hop on the Basics bandwagon. Here's an oldy of mine with some menopause and hormone therapy background. WARNING: rampant pharmaceutical company sexism ahead. Do not attempt to communicate or reason with Zuska for at least 4 hours after reading. Rumor also has it that Tara is advocating for a beat-down.
Parts II and III are here and here.
The Transition to Menopause
Menopause is defined as the cessation of ovarian function. It occurs at the average age of 50 in women, is accompanied by a decrease in circulating levels of estrogen and progesterone associated with the loss of…
neurotopia | June 26, 2006Inspired by Rush Limbaugh's apparent erectile dysfunction, I decided that today's Evil Journal Club should address the "other" potential uses of PDE-5 inhibitors, the most (in)famous of which is Viagra.
Phosphodiesterase type 5 (PDE-5) is an enzyme that breaks down cyclic GMP. We've known for a while that cGMP is important for signal transduction and ultimately for learning and memory processes, and that nitric oxide (NO) can stimulate production of cGMP. Interestingly, changes in this NO-cGMP signaling pathway have been implicated in aging, providing a potential link to deteriorating…
neurotopia | June 9, 2006...you might not know what to do
you might have to think of
how you got started
sittin' in your little room
--The White Stripes
Welcome to the second incarnation of Neurotopia! The old incarnation can be found here, although lately it has just been a collection of posts where I complain about how Blogger stinks. But no more! Now I'm here on this slick new platform! The SEED overlords pulled a mean trick on me: they set up the new blog launch mere hours before I'm supposed to hit the road and celebrate my 8th anniversary by accompanying Mrs. Evil Monkey to Fallingwater for the weekend.…