blood clotting
dblum | February 1, 2010On Friday, a 41-year-old Missouri woman was charged with poisoning her granddaughter with an anti-clotting medication. The reason: she wanted to scare the one-year-old's parents into uniting over the child's illness and giving up their divorce plans.
The poisoning was discovered when the little girl began bleeding uncontrollably from her mouth and nose. Although doctors treated her successfully, they expressed concern about long-term damage. High exposure to anti-coagulents, usually members of the Warfarin family of drugs, such as Coumadin, has been linked to heart and bone damage.
Bizarre as…
sporte | May 5, 2009Warfarin, a commonly used anti-clotting drug, sold under the brand name of Coumadin, has a been a poster child for the promise of pharmacogenomics and personalized medicine.
The excitement has come from the idea that knowing a patient's genotype, in this case for the VKORC1 and CYP2C9 genes, would allow physicians to tailor the dose of the drug and get patients the correct dose more quickly.
And it seems obvious that a test that would allow doctors to predict your ability to metabolize warfarin, would be a great thing, right?
Figure 1. Human Cytochrome P450 Cyp2c9 bound to Warfarin…