Clinical trials
oracknows | October 31, 2007Having gotten into the whole idea of blogging about peer-reviewed research yesterday and even using a spiffy new icon to denote that that's what I'm doing, originally I had planned on looking up another interesting article or pulling one from my recent reading list and blogging about it. Then, realizing that Breast Cancer Awareness Month is over after today, I happened to come across an article that reminds me of something that's appropriate for today, namely Halloween. Yes, it's that mercury maven of mavens, that tireless crusader who thinks he found that the Amish don't get autism and,…
oracknows | October 30, 2007
Dave Munger and others have been spearheading an effort to promote the acceptance of a specific logo that science bloggers (ScienceBloggers, included) can use to let the reader know that the topic of a blog post is a discussion of real, peer-reviewed research. Use of the logo, which I've used for this post, means a blogger is not just commenting on research that's been reported in the media, but rather has gone, so to speak, straight to the horse's mouth to look up the original peer-reviewed journal article. It's a worthy effort, and I plan on going back through the last few months of…
terrasig | October 29, 2007Perhaps you've stumbled on this post late at night while tending to a child suffering from a cold.
Well, I've been reading a fair bit lately about the 18-19 October meeting of the FDA's joint meeting of their Nonprescription Drug and Pediatric Advisory Committees, trying to make sense about calls to restrict or prohibit the use of cough and cold medicines in children under age 6. There is so much material on the subject that I have hesitated to post on the issue until I received the following e-mail from an old friend, fellow scientist and parent, North of 49:
Okay, so I'm writing to you to…
tsmith | October 25, 2007For those of you who might not brave the comments threads on any HIV post, you may have missed this tidbit of information. I've written about "investigative journalist" Liam Scheff previously; he's an HIV "dissident" and author of a story from a few years back titled "The House that AIDS Built". In this, he claimed that HIV+ children had been removed from their parents' homes and force-fed "toxic" drugs to treat their condition (which of course, he claims is based on "inaccurate" HIV testing in the first place):
The drugs being given to the children are toxic - they're known to cause…
oracknows | October 25, 2007I approach this topic with a bit of trepidation. I say this not because I'm unsure that I'm correct in my assessment of the article that I'm about to apply some Respectful Insolence⢠to. Rather, it's because the last time I brought up anything having to do with abortion, it got ugly. The topic is such a polarized one that virtually anything one says is sure to attract vitriol. Regardless, though, this article by Dennis Byrne, a columnist for the Chicago Tribune and the "study" to which it refers, are so appallingly idiotic that even fear of touching the third rail of American politics will…
oracknows | October 22, 2007I was thinking of calling this post Jenny McCarthy and Julie Deardorff: Two crappy tastes that taste crappy together, but I've already used that joke with Jenny McCarthy and Oprah Winfrey. Besides, Julie Deardorff isn't nearly as famous as Oprah, although, as I've discussed before, she's probably even more credulous than Oprah towards the lastest dubious feel-good story about autism. Of course, this means that Deardorff and McCarthy are custom-made for each other, and, unfortunately, the antivaccination columnist for the Chicago Tribune has finally hooked up with the former Playmate of the…
terrasig | October 19, 2007In a post the other day, we noted that the semi-synthetic natural product, ixabepilone, approved for advanced breast cancer was derived from a soil bacterium. Colleague PharmCanuck reminded us that the soil is not a new source for drugs: the anthracyclines, daunorubicin and doxorubicin, are derived from a strain of Streptomyces found growing on a 13th century castle along the Adriatic Sea (hence the brand name for doxorubicin, Adriamycin). Amazingly, Adriamycin remains a foundation of many breast cancer chemo regimens more than 30 years after its approval.
While we speak here quite often…
oracknows | October 17, 2007I've written before about how one of the favorite tactics of those who do not like my insistence on applying skepticism, science, and critical thinking to the claims of alternative medicine or my refusal to accept a dichotomy between "alternative" and "conventional" medicine is to try so smear me as some sort of "pharma shill." It's happened so often ever since my Usenet days that I even sometimes joke about it preemptively sometimes when writing skeptical posts or make smart aleck comments asking where I can sign up to get those big checks from big pharma, given that they'd almost certainly…
oracknows | October 2, 2007Last week, I wrote about an overhyped acupuncture study that purported to show (but didn't, really) that acupuncture is more effective than "conventional" therapy in the treatment of low back pain. This story reverberated through the Internet and blogosphere as "proof" that acupuncture "works" when in reality the study was very weak evidence of any effect due to needles being placed into the skin and only showed that meridians are a meaningless concept (i.e., the finding that sham acupuncture was just as effective "real" acupuncture). If acupuncture does do anything, this study was pretty…
oracknows | October 1, 2007I've written a lot about dichloroacetate, a.k.a. DCA (my last post here, along with links to my previous posts), the small molecule drug that burst onto the scene after Evangelos Michelakis of the University of Alberta published a paper in Cancer Cell in January describing strong anti-tumor activity in preclinical models (in this case, a rat model) of several different cancers.
Scientifically, DCA is interesting because, unlike many previous chemotherapeutic agents, it targets the energetics of the cell, specifically an alteration in cancer cells known as the Warburg effect. This is an idea…
oracknows | September 27, 2007I'm almost beginning to feel sorry for the mercury militia.
Think about it. They've been claiming for the past several years that the mercury in the thimerosal used as a preservative in childhood vaccines is a cause of autism. If you believe Generation Rescue, A-CHAMP, SAFEMINDS, and various other activist groups, vaccines are the root of all neurodevelopmental evil, culminating in what to them seems to be the most evil of evil condition, autism. Yet, in study after study in the new millennium, no correlation has been found to implicated their favorite bête noire thimerosal, which serves as…
oracknows | September 26, 2007Never let it be said that Orac doesn't give the people what they want.
Well, most of the time, anyway.
What I'm referring to is a recent German study about acupuncture for low back pain that's been making its way around the media. I had actually been planning on commenting about it yesterday, but Iranian President (and Holocaust denier) Mahmoud Ahmadinejad's speech at Columbia University intervened and took me on one of my occasional diversions away from science and medicine into the history of the Holocaust, Holocaust denial, and politics. In just that two day interval, I've been deluged…
oracknows | September 24, 2007Pity poor John Ioannidis.
The man does provocative work about the reliability of scientific studies as published in the peer-reviewed literature, and his reward for trying to point out shortcomings in how we as scientists and clinical researchers do studies and evaluate evidence is to be turned into an icon for cranks and advocates of pseudoscience--or even antiscience. I first became aware of Ioannidis two years ago around the time of publication of a paper by him that caused a stir, entitled Contradicted and Initially Stronger Effects in Highly Cited Clinical Research. In that study,…
oracknows | September 10, 2007Sadly (with regards to vacation) and not-so-sadly (with regards to the events of last week), it's time to dive headlong back into the "real world" at work, starting with clinic today. It also means it's time to get back to my favorite hobby (blogging) in a much more regular way, although I will say that a relatively prolonged break from the blog was good, and my traffic only suffered mildly for it. I may have to do it more often, if only to keep things fresher.
One of the tasks that confronted me this weekend as I got ready to face a full week back at work was to try to catch up on all the…
oracknows | September 5, 2007Due to a death in the family, I have to go back into the vaults of the old blog for some more reruns. Regular blogging should resume in a day or two This particular post first appeared on June 16, 2005.
One of the overarching themes of this blog has been skepticism in the claims of alternative medicine. Consequently, a recurring type of post has been the debunking of some claim or other made by the proponents of alternative medicine. Sometimes debunking these claims is like shooting fish in a barrel, allowing for humorous play with the concept, and sometimes the claims are a bit harder to…
oracknows | September 4, 2007A couple of weeks ago, before I went on vacation, the BBC aired a two-part documentary by Richard Dawkins entitled The Enemies of Reason. Part One dealt primarily with the paranormal and various New Age phenomena, while Part Two, which aired mere days before my London trip, dealt squarely with alternative medicine in an uncompromising fashion. One key segment of Part Two discussed the bizarre magical thinking that is known as homeopathy. Although I quibbled a bit about certain aspects of how Dawkins presented homeopathy, overall I thought it was the best deconstruction on video of the…
oracknows | August 16, 2007[Note: Part I is here.]
I tell ya, I stay up all night putting the finishing touches on a grant, and what happens? Mark Hoofnagle over at Denialism.com finds a real hum-dinger of stupidity published in the editorial pages of the Wall Street Journal. Unfortunately (or fortunately, given the rampant stupidity that appears to be going on in this article), I do not have a subscription to the WSJ; however, a little Googling found the whole text here. I've written about this conflict before, and it's a recurring theme in the multiple posts that I've done regarding dichloroacetate (DCA), the small…
oracknows | July 31, 2007I was going to write about a recent study that purports to claim that smoking pot causes schizophrenia that's been making the rounds lately. Unfortunately (or fortunately, depending on how you see it), this week's host of the Skeptics' Circle, Mark Hoofnagle, beat me to it.
Can you say, "Correlation does not necessarily equal causation"?
The reporters who hyped the study and the investigators who enabled them should repeat this 100 times. Maybe it'll sink in.
terrasig | July 30, 2007This post appeared originally on 8 Feb 2006 at the old site for this blog. A frequent reader and commenter, Joe, suggested that I repost it here as it illustrates many common problems with clinical trials of botanical medicines.
You'd think the funding folks would learn at the NIH National Center for Complementary and Alternative Medicine (NCCAM). But, not as evidenced by the report in tomorrow's New England Journal of Medicine detailing the lack of efficacy of saw palmetto (Serenoa repens) extract in the treatment of benign prostatic hypertrophy.
Yet another well-designed double-blind,…
tsmith | July 27, 2007XDR-TB has been in the news quite a bit lately, largely thanks to Andrew Speaker's notoriety. Even though his TB was later re-classified as "just" multi-drug resistant (MDR-TB) instead of the initial extremely drug resistant (XDR) type, it did serve to raise awareness about the issues public health authorities face when dealing with something like tuberculosis--and where the gaps are in the control of its spread. (Indeed, a breaking story out of Taiwan shows how difficult it can be to enforce a travel ban).
However, while XDR-TB is rather new on the radar of the general public (and even…