genome browsers
dgmacarthur | March 9, 2009Jan Aerts discusses the problem of incorporating information on large-scale genomic rearrangements into genome browsers.
Genome browsers such as UCSC and Ensembl are fantastic for presenting many types of genomic information, such as the position and orientation of protein-coding genes or the location of small-scale genetic variants. However, their linear arrangement makes it very difficult to use them to present large-scale genetic variations (duplications, deletions or inversions). This is a serious problem, as these types of genetic variants are surprisingly common in the human genome, and…