resistance
dr. dolittle | August 31, 2016Tasmanian devils are rather large carnivorous marsupials. By large, I mean the world's largest.
In only 2 decades, the population of Tasmanian devils have declined by about 85%, landing these animals on the endangered species list. The cause: an infectious cancer called devil facial tumor disease (DFTD). As the name implies, this cancer causes facial tumors that grow so large, the victims starve to death in as little as 6 months from an inability to eat. What makes this cancer particularly devastating to a population is how it spreads between animals through bites and the one thing Tasmanian…
dr. dolittle | April 6, 2016
Today was the final day of the meeting.
Dr. Joe Thompson (Franklin and Marshall College) spoke about oblique striated muscles, which get their name from the diagonal pattern formed by the location of the Z-lines. This type of muscle is common among cephalopods, nematodes, tunicates, molluscs, etc.
Dr. John Whiteman (University of Wyoming) gave a fascinating talk about polar bears and whether hunting on the shore as compared to the sea ice helped the animals replenish stores after hibernation or fasting as well as how foraging patterns affected activity levels.
Dr. Michael Butcher (…
sastyk | October 3, 2011A number of readers have asked me what I think about the Wall Street protests. In general I think public protest is usually a good thing, and I'm pleased to see demonstrations in favor of good things like corporate accountability and against bad things like climate change. I think there are plenty of reasons for political activism in our country, and am always pleased by it.
On the other hand, do I think that this is the beginning of something profound and important? I can't say for sure, but I would guess not. Protesting Wall Street isn't a bad idea - but there's a fundamental problem in…
rallain | August 12, 2010There is something I am working on that will need some type of angle sensor. I am going to use a potentiometer. First, who came up with that name? Isn't this name the same as a voltmeter? Something is wrong with that name. How about we just call it a variable resistor or something like that?
These things are pretty easy to find if you have some old electronic stuff. Here is one I found in our "junk room".
This one was used in a lab as a variable resistor with plugs built in. The normal potentiometer has three connections; one for each end and one for the variable position in the…
mmckenna | July 7, 2010(You leave the country for a few days -- I spoke at a conference in Brussels, which was was lovely, thanks for asking -- and all kinds of news breaks out. So, sorry to be late on this, but it's an important issue.)
Last week, the Food and Drug Adminstration took the first (baby, mincing, tentative) steps to address the problem of antibiotics being used in animal agriculture, not to treat disease, but to make animals grow up to market weight faster. This practice -- variously called subtherapeutic dosing, growth promotion, and "for production purposes" in the FDA's exceedingly careful…
mmckenna | June 24, 2010There's a troubling item in this afternoon's issue of the CDC's Morbidity and Mortality Weekly Report or MMWR: The first report in the United States of a novel resistance mechanism that renders gram-negative bacteria extremely drug-resistant and that has been linked to medical care carried out in India or Pakistan.
The short item describes three isolates (E. coli, Klebsiella pneumoniae and Enterobacter cloacae) found in three patients in three states between January and June of this year. All three isolates produced New Delhi metallo-beta-lactamase (NDM-1), which has never been recorded in…
mmckenna | June 17, 2010A set of papers published this month in two journals provide an unsettling glimpse into the rocketing incidence and complex epidemiology of one really scary pathogen, Acinetobacter baumanii.
In the all-star annuals of resistant bugs, A. baumanii is an underappreciated player. If people -- other than, you know, disease geeks -- recognize it, that is because it's become known in the past few years for its propensity to attack wounded veterans shipped to military hospitals from Iraq and Afghanistan, earning it the nickname "Iraqibacter." (Important note: Steve Silberman of Wired magazine took an…
mmckenna | June 15, 2010The Center for Global Development, a DC think-tank, is releasing what looks like a thoughtful report aimed at refocusing policy debates over drug resistance toward the epidemic's global impact, with particular attention to the the developing world.
From the report's preface:
Problems with drug resistance have moved from the patient's bedside to threaten global public health. Drug resistance has dramatically increased the costs of fighting tuberculosis (TB) and malaria, has slowed gains against childhood dysentery and pneumonia, and threatens to undermine the push to treat people living with…
mmckenna | June 15, 2010Via the Journal of the American Medical Association, a report from Spain: the first recorded outbreak, in a Madrid hospital, of Staphylococcus aureus resistant to linezolid (Zyvox), one of only a few drugs still available to treat very serious infections of drug-resistant staph, MRSA. This is bad news.
Background: The M in MRSA stands for methicillin, the first of the semi-synthetic penicillins, created by Beecham Laboratories in 1960 in response to a worldwide 1950s outbreak of penicillin-resistant staph. The central feature of the chemical structure of both penicillin and methicillin is an…
pronald | April 30, 2010Tonight's dessert is plum cake:
Tante Lissy's Flaumen Kuchen (Plum Cake)
1 c Butter
1 c Sugar
1 Egg
2 tsp Almond extract (or vanilla)
1 tsp Salt
1 c White fl our
1 c Barley
10 Plums, pitted and cut in half
2 Tbsp warmed apricot jam
1. Beat together butter and sugar. Add in egg, almond or vanilla extract,
and salt.
2. Mix in fl our and barley to form a dough.
3. Pat 2/3 of the dough into an ï¸-inch pan with removable rim. Arrange plums,
cut side down, in pan.
4. Lattice rest of dough on top; drizzle with apricot jam.
5. Bake at 350°F for 45 minutes.
I saved some Santa Rosa plums last summer…
edyong | December 31, 2009If you search for decent definitions of evolution, the chances are that you'll see genes mentioned somewhere. The American Heritage Dictionary talks about natural selection acting on "genetic variation", Wikipedia discusses "change in the genetic material of a population... through successive generations", and TalkOrigins talks about changes that are inherited "via the genetic material". But, as the Year of Darwin draws to a close, a new study suggests that all of these definitions are too narrow.
Jiali Li from the Scripps Institute in Florida has found that prions - the infectious proteins…
edyong | May 9, 2009
Immunity to viral infections sounds like a good thing, but it can come at a price. Millions of years ago, we evolved resistance to a virus that plagued other primates. Today, that virus is extinct, but our resistance to it may be making us more vulnerable to the present threat of HIV.
Many extinct viruses are not completely gone. Some members of a group called retroviruses insinuated themselves into our DNA and became a part of our genetic code. Indeed, a large proportion of the genomes of all primates consists of the embedded remnants of ancient viruses. Looking at these remnants is like…
purepedantry | March 16, 2009If you work in infectious diseases in a hospital -- or frankly if you work anywhere in a hospital -- the emergence of antibiotic resistant bacteria is a serious problem. You have to be constantly aware of what the right drug is to prescribe to ensure its maximum effectiveness, and -- though rare -- there are some bacterial infections for which we have no good drugs.
This is why I was very intrigued about researchers trying to design antibiotics that would not create resistant bacteria:
Vern L. Schramm, Ph.D., professor and Ruth Merns Chair of Biochemistry at Einstein and senior author of the…