Skepticism/Critical Thinking
oracknows | December 15, 2016I don’t know if other bloggers out there have experienced anything like this, but I’ve experienced this a few times since starting this blog. Last night I started writing about an article that—or so I thought— was the perfect distillation of the message of the NCCIH and its desire to co-opt nonpharmacological treatments for pain as being “integrative,” “complementary” or “alternative.” As I sometimes do when I’m tired and, no matter how hard I try, can’t motivate myself to finish it before dozing off, I chugged through about half of what I saw as the ultimate length, meaning to get up in the…
oracknows | December 13, 2016I’ve seen it noted that our new President-Elect seems to be selecting his cabinet officers and directors of federal bureaucracies based on how much they oppose the mission of the department they are supposed to head. For instance, to head the Department of Health and Human Services, he picked an orthopedic surgeon who belongs to an organization utterly opposed to any role of the federal government in health care and who himself looks poised to dismantle as much of the Affordable Care Act as he can. For the Department of Energy, he picked Rick Perry, a man so dumb that when he was asked during…
oracknows | December 12, 2016I wasn’t always a skeptic. Maybe I should rephrase that. I’ve probably always been a skeptic since a young age. It’s just that I didn’t start self-identifying as one until around 1998 or so. Oddly enough, my “gateway drug” into more organized skepticism was refuting Holocaust denial. I’ve told the tale on multiple occasions before, the first time on the occasion of the 60th anniversary of the liberation of Auschwitz (nearly 12 years ago now), about how I first discovered Holocaust denial. I always encourage new readers to read the whole thing, but the CliffsNotes version is I encountered the…
oracknows | December 11, 2016Old fart that I am, I’ve been a fan of The Rolling Stones since the mid-1970s, when I was in junior high school. Over the years, I’ve accumulated pretty close to all of their studio albums—and even bought multiple remastered versions of classics like Exile on Main Street and Beggar’s Banquet—and got access to the rest when I discovered the joy of streaming through Apple Music. Granted, the Stones went through a rough patch, creatively speaking, in the 1980s (the less said about Under Cover and Dirty Work, for instance, the better) and nothing they’ve done since the late 1970s has lived up to…
oracknows | December 8, 2016Yesterday, I noted the passage of the 21st Century Cures Act, a Hobson’s choice of a bill for those of us who support increased biomedical research funding that basically said: You can have an increase in the NIH budget. You can have the Cancer Moonshot. You can have President Obama’s Precision Medicine Initiative and his brain mapping initiative. You can have additional funding to combat the opioid crisis. You can have all that, but only if you also accept a grab bag of longstanding pharmaceutical industry wishes, such as new pathways to approve drugs and devices with a lower standard of…
oracknows | December 7, 2016Well, it’s done.
Today, the Senate passed the 21st Century Cures Act, a bill designed to weaken the FDA and empower pharmaceutical companies, sending it to President Obama’s desk. There’s no way Obama won’t sign it, as it contains provisions funding his Precision Medicine Initiative, and he supported it all along. For all its flaws, I knew the bill’s passage was inevitable since after the election, when Senate Majority Leader Mitch McConnell stated that the bill was a priority. I knew it even more when the Senate linked the bill to the “Cancer Moonshot” initiative spearheaded by Vice…
oracknows | December 4, 2016I’ve frequently written about a form of medicine often practiced by those who bill themselves as practicing “complementary and alternative medicine” (CAM) or “integrative medicine” (or, as I like to refer to it, “integrating” quackery with medicine). I’m referring to something called “functional medicine” or, sometimes, “functional wellness.” Over the years, I’ve tried to explain why the term “functional medicine” (FM) is really a misnomer, how in reality it is a form of “personalized medicine” gone haywire, or, as I like to refer to it, as “making it up as you go along.” Unfortunately,…
oracknows | December 2, 2016Back in the day, I used to write posts with titles like When the outbreaks occur, they’ll start in California. I even wrote a followup, When the outbreaks occur, they’ll start in California, 2014 edition. The reason, of course, was that California was one of the epicenters of vaccine hesitancy as well as the home to some high profile antivaccine-sympathetic physicians, such as Dr. Bob Sears (who’s known for making Holocaust analogies about bills tightening school vaccine mandate requirements) and Dr. Jay Gordon (who’s known for continuing to claim, against all evidence, that vaccines cause…
oracknows | November 30, 2016A week and a half ago, a conference was held at the NYU Langone Medical Center, Confronting Vaccine Resistance: Strategies for Success. It featured speakers and panelists whom I admire quite a bit, including Paul Offit, the man who is to antivaccine loons Satan, Darth Vader, Voldemort, and Sauron all rolled up into one. Also featured were Richard Pan, the California state senator who co-sponsored SB 277, which passed and is now a law that bans nonmedical exemptions to school vaccine mandates; bioethicist Arthur Caplan, a strong advocate for vaccines; Dorit Reiss, a law school professor and…
oracknows | November 29, 2016I’m always hesitant to write about matters that are more political than scientific or medical, although sometimes the sorts of topics that I blog about inevitably require it (e.g., the 21st Century Cures Act, an act that buys into the myth that to bring "cures" to patients faster we have to neuter the FDA and a retooled version of which is still being considered). This is one of those times. Yesterday, I woke up to the news that President-Elect Donald Trump had chosen Rep. Tom Price (R-GA) as his new Secretary of Health and Human Services. The Department of Health and Human Services (DHHS),…
oracknows | November 28, 2016I don’t have many “rules” per se about blogging, but one informal rule that I do live by is that I never blog about a study if all I can access is the abstract. In general, I insist on having the complete study before I will blog it, because to me the abstract isn’t enough. Basically, if I’m going to blog a study, I generally want to do it right and be able to read the whole paper, because that’s the only way to properly analyze a paper. I find this rule particularly important when analyzing the latest bit of antivaccine pseudoscience, especially because most antivaccine activists don’t go…
oracknows | November 27, 2016It’s been a long time since I’ve encountered Glenn Sabin. You might remember him, though. He runs a consulting firm, FON Therapeutics, which is dedicated to the promotion of “integrative” health, or, as I like to put it, the “integration of pseudoscience and quackery with science-based medicine. What I remember most about Sabin is how he once proclaimed that “integrative medicine” was a brand, not a specialty. Unfortunately, he was correct in his assessment. Basically, he declared, “CAM [complementary and alternative medicine] is dead. The evolution of evidence-based, personalized integrative…
oracknows | November 25, 2016This post is a bit later than usual, but there’s a good reason for it. Last night, I was in full food coma, having consumed the traditional Thanksgiving feast, along with a fair amount of wine. Besides, even a sometimes arrogant bloviator like myself, who uses a pseudonym based on a fictional, near-all-knowing supercomputer from a 35-year-old British cult science fiction series needs a break now and then.
So today I’ll be, for the most part, slumming a bit today as I recover. What better place to look for material when you’re not interested in exerting yourself too hard than the antivaccine…
oracknows | November 17, 2016I’ve frequently written about what I like to refer to as “quackademic medicine,” defined as the infiltration of outright quackery into medical academia, particularly medical schools and academic medical centers. There’s no doubt that it’s a significant problem as hallowed institutions like Memorial Sloan-Kettering Cancer Center embrace nonsense, pseudoscience, and quackery in the name of “integrative medicine.” It goes far beyond MSKCC, however, with Dana-Farber and other elite institutions having apparently bought into the need to study prescientific vitalistic quackery.
One area that’s…
oracknows | November 14, 2016The Society for Integrative Oncology (SIO) doesn’t like me much. I understand. I haven’t exactly been supportive of the group’s mission or activities. So it wasn’t surprising that SIO wrote letters trying to rebut a Perspectives article on “integrative oncology” that I published in Nature Reviews Cancer two years ago. What depressed me about that encounter was that one of the complaints the SIO had about my article was that it spent too much verbiage discussing homeopathy as one pseudoscientific treatment that “integrative” oncology “integrates” with science-based medicine and no one uses…
oracknows | November 13, 2016John Weeks has long been an activist for alternative medicine—excuse me, “complementary and alternative medicine” (CAM) or, as it’s more commonly referred to these days, “integrative medicine.” Despite his having zero background in scientific research or the design and execution of experiments and clinical trials, for some bizarre reason in May he was appointed editor of the Journal of Alternative and Complementary Medicine (JACM). It didn’t take him long at all to use his new post to launch a nasty broadside against CAM critics in general (such as yours truly) and those who criticized a…
oracknows | November 11, 2016If you’re a skeptic dedicated to promoting science and reason, these are scary times. My country, the United States of America, just unexpectedly elected a racist, misogynistic, conspiracy-mongering, scientific ignoramus (who, by the way, is rabidly antivaccine) as its next President thanks to the political relic known as the Electoral College. In actuality, Hillary Clinton won the popular vote by close to 350,000 votes at the last tally I checked this morning, but now, as in 2000, thanks to the Electoral College, the candidate with the most popular votes is not President-Elect. Hillary…
oracknows | November 10, 2016Well, I’m back.
Yes, late last night, I re-entered returned home from vacation in Mexico before our new President-Elect has a chance to build his wall. I was so exhausted that I had no time to write anything and remain so. At least I wasn’t stupid enough to go back to work today and instead took the whole week off. Like most of you, I’m still processing he cluster—oh, wait, no major profanity here—that was the US election, whose results definitely put a damper on the trip home.
In particular, I fear for what the new administration will do to science in this country, and might write about that…
oracknows | November 9, 2016Yesterday, I wrote about alternative medicine clinics in Germany that offer a combination of alternative cancer cures plus experimental therapeutics administered improperly outside the auspices of a clinical trial. In particular, I discussed two cases. The first was British actress Leah Bracknell, who is raising money to go to one of these alternative cancer clinics to treat her stage IV lung cancer. the second was a British woman named Pauline Gahan, who was diagnosed with metastatic stomach cancer and has thus far spent £300,000 for a combination of vitamin infusions, “detox,” and Keytruda…
oracknows | November 8, 2016A couple of months ago, I discussed patient deaths at an alternative medicine clinic in Europe, where a naturopath named Klaus Ross had been administering an experimental cancer drug (3-bromopyruvate, or 3-BP) to patients outside the auspices of a clinical trial. 3-BP is a drug that targets the Warburg effect, a characteristic of cancer cells first reported in the 1920s by Otto Warburg in which the cancer cell changes its metabolism to shut off oxidative phosphorylation (the part of glucose metabolism requiring oxygen that produces the most energy) to rely almost exclusively on glycolysis and…