urinary tract infections
ksnyder | June 3, 2011In news that may shake the cranberry juice industry to its core, new atomic-level "snapshots" reveal how bacteria such as E. coli produce and secrete sticky appendages called pili, which help the microbes attach to and infect human bladder cells.
These crystal structures -- produced at the National Synchrotron Light Source (NSLS) at Brookhaven Lab and the European Synchrotron Radiation Facility in Grenoble, France -- unravel a complex choreography of protein-protein interactions that will aid in the design of new antibacterial drugs. Finding ways to interfere with pili formation could help…
gregladen | August 12, 2010Chronic infection is, in a way, the new emerging infectious disease. Many pathogens are relatively tenacious when they infect elderly individuals or individuals who are otherwise not fully immunocompetent, and such individuals are, thanks to modern medical technology and practice, more common in the population. Resistant bacteria can cause chronic infection. It is interesting to see more research oriented specifically towards the problem of chronic infection as a problem in and of itself, and a paper just out by Hannan, Mysorekar, Hung, Isaacson-Schmit and Hultgren, in PLoS Pathogens, is…