Grading the news: Metal ion complier edition.

So I'm looking around at news stories and I find one on Eurekalert about neurodegenerative disease entitled "Researchers link metal ions to neurodegenerative disease". My first thought: "Wow." Then I read the article. Then I thought: "Wow. Eurekalert screws it up (again)."

According to the news snippet: researchers from Emory have found that a certain way that metal ions bind to amyloid fibrils in the brain appears toxic to neurons. (The build up of Amyloid fibrils in the brain is linked primarily to Alzheimer's but also to Creutzfeldt-Jakob syndrome and Parkinson's disease.) So I'm thinking "Back to the aluminum causes alzheimer's hoopla?" No so fast says the article. It says that Aluminum has been ruled out so Copper, Zinc, and Iron are the prime suspects. Cu, Zn, and Fe? So I'm starting to get a bit skeptical.

From the news clip:

While little is known about the exact mechanisms governing the formation of amyloid fibrils, the study's results suggest that the exact way amyloid binds to copper ions affects the fibers' architecture, rate of propagation and their effect, if any, on surrounding neurons.

[...]

The scientists, collaborating throughout the United States and across Emory, focused on the smallest individual unit of amino acids that make up amyloid fibrils. By determining only an individual unit's physical and chemical properties when binding with metal, the researchers were able to determine the activity governing the assembly and toxicity of whole fibrils with respect to their effect on brain cells.

"We showed that the activity of this minimal unit actually replicates the activity of the whole fibril on the neuronal cell. And it does so by binding the metal in a specific way," says Dr. Lynn.

Um, that's about it. So doesn't it seem likely that it's still a problem with amyloid folding improperly that causes the metal ion binding that then goes on aggregate? Otherwise, since every person on the planet is loaded up with Cu, Zn, and Fe, wouldn't we all have the diseases? In other words, the etiology of the disease has nothing to do with metal ions, although they appear involved in the progression of the disease. So we figured out something about how the large scale folding happens and narrowed down another avenue to investigate for cause (What is causing the metal ions to bind in that particular spot in a pre-disease state. The study comes out in PNAS this week.

Grade: D, Okay, so the article writer usually doesn't get to choose the hed, but the article is REALLY short on details or any summary about what the paper really shows. I blame both writers; it's AAAS, for goodness sake!

Tags

More like this

This three-dimensional reconstruction of an amyloid fibril (found at Discover) was created by Nikolaus Grigorieff and his colleagues at Brandeis University, by computer processing of a transmission electron cryomicroscopy image. It is the most detailed image yet of the abnormally folded protein…
Anne Hart is still on her anti-frankenfishscapade. Actually, this latest article looks like she plagiarized her last article and added stuff about prions. She still doesnt understand retroviruses or gene therapy: Farmed fish start out by having the rous sarcoma virus implanted into a specialized…
tags: Bovine spongiform encephalopathy, BSE, mad cow disease, Creutzfeldt-Jakob Disease, CJD, pathogenic mutation, prion protein gene Image: Orphaned. Mad Cow Disease, technically known as Bovine Spongiform Encephalopathy (BSE), is one of a group of transmissible diseases that destroy brain…
ALZHEIMER'S Disease is the most common form of dementia, affecting an estimated 30 million people worldwide. The cause of the condition is unknown, but the prime suspect is amyloid-beta (Aβ), a 42-amino acid peptide which accumulates within neurons to form insoluble structures called senile…