When we complained the other day about World Organization for Animal Health (OIE) Director General Bernard Vallat's ill-considered remarks about how stable H5N1 was and that earlier fears were "overblown" we were not alone. Mike Osterholm at CIDRAP issued a similar remonstrance and the latter was publicized by the folks at Avian Flu Trackers on a press release that was picked up by a number of papers. Now DG Vallat is busy trying to extricate his foot from his mouth (or wherever he lodged it):
At an informal meeting with the press on 10/1/08 , the Director General of the OIE, Dr Bernard Vallat presented an overview on current and future activities of the organisation while addressing the need for global animal health strategies to control emerging and re-emerging infectious animal diseases worldwide.In this context, the issue of highly pathogenic avian influenza and the current situation with H5N1 was raised by some of the reporters.
Dr Vallat said - as he has said in the past - that although the H5N1 virus is extremely virulent, it has shown to be quite stable over the last few years and its epidemiological behaviour remained the same from the beginning of the crisis in 2003. He added that this observed stable behaviour of the H5N1 strain of the virus does not allow ruling out the risk of a mutation into a new dangerous form for humans, thus becoming a potential candidate for an avian influenza pandemic. (OIE, Press statement)
Translation: Yes, I said it, but I was just sitting around bullshitting with some press buddies. And anyway, it wasn't wrong.
Since M. Vallat seems to be using the word "stable" as part of a private language I can't comment on what he means except to say there doesn't seem to be anything particularly stable about this virus. AS far as I'm concerned his clarification only emphasizes he doesn't seem to understand what he is dealing with. This virus has changed in a great many ways, well documented. Most of the changes are of unknown significance. As for its epidemiological behavior remaining the same over years, perhaps if we had good epidemiological data we could say that. We don't. The data are scarce. The only epidemiological fact I feel confident about is that so far there hasn't been a pandemic. But there is a broad range of epidemiological behavior (whatever he means by that) which falls short of pandemic behavior and about which we know little. Has the host range increased? What is the true geographic reach? Has transmissibility changed in any way? Are the modes of transmission changing? Where are the reservoirs? Maybe all of those things have remained the same since 2003. If so, show me the data.
It's true that M. Vallat adds all the usual caveats that there could be a pandemic at any time, that we need to strengthen national veterinary services and infrastructure and collaborate between disciplines. But his statements, which were careless and were probably spiced with more than a touch of arrogance, don't make any of those things easier to accomplish.
Here's a sign for your office, M. Vallat: Engage brain before opening mouth.
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Yep, his statements just dont square with the facts. It is as I said that everyone needs to get on the same page of music and start singing it, right or wrong. Its like going to the beach at Banda Aceh.
I distinctly remember that one of the beaches near Phuket that a 14 year old stood up when the water started running out to sea screamed at everyone to get inland and wouldnt leave until they did. Her own mom didnt believe her until she started to get physical.
We need some more fourteen year olds to call the shots.
http://news.yahoo.com/s/afp/20080117/wl_sthasia_afp/healthindiaflu_0801…
Classic case of not being accurate. Maybe what he should have said is that the virus has not been able to increase its infectivity toward humans that much in the last 10 years, although that is not a predictor of what the virus might be able to do in the next 10 years or even the next 10 days.
stable: no reassortment with other serotypes outside China.
"Avian Flu Trackers" ?
Thanks revere.
"Now DG Vallat is busy trying to extricate his foot from his mouth (or wherever he lodged it):"
LOL
Hi anon. You always give me a chuckle when I see you around. We never see you that often on AFT these days. I believe he may have meant Avian Flu Talk, but that's quite alright. The whole thing was somewhat of a joint effort either way.
Marissa-In actuality, what Vallat should have done was to have kept his mouth shut.
I got over 30 emails in reference to it as to whether it was over or not. I sent them the above EM, the India story and told them that in the esteemed estimate of three local scientists that work at an even more esteemed facility that they thought it was coming and soon.
Here is a link to the latest NEJM article on H5N1. I believe with the number of different clades circulating in the world, stable is incorrect terminology.
"The New England Journal of Medicine (Vol. 358, Issue 3, pp. 261-273 of 17 January 17 2008) has just published online a detailed review by the Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus on human infection with H5N1 avian influenza. The review, entitled Update on avian infleuenza A (H5N1 virus infection humans, is available online at: http://content.nejm.org/cgi/content/full/358/3/261?query=TOC
It is accompanied by a supplementary appendix, which is also available online (at: http://content.nejm.org/cgi/data/358/3/261/DC1/1)."
Andrew: I'm on the road but plan to have a quick summary for tomorrow morning's post.
this is just normal evolution. You find the same
with other flu-serotypes. No argument for
"instability". What did we expect 2 years ago ?
Classic case of not being accurate. Maybe what he should have said is that the virus has not been able to increase its infectivity toward humans that much in the last 10 years, although that is not a predictor of what the virus might be able to do in the next 10 years or even the next 10 days.
Posted by: Marissa | January 17, 2008 2:31 PM
Right. Or the next 10 minutes!
Dave Briggs :~)