Neanderthal Extinction by Competitive Exclusion:
Despite a long history of investigation, considerable debate revolves around whether Neanderthals became extinct because of climate change or competition with anatomically modern humans (AMH).
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We apply a new methodology integrating archaeological and chronological data with high-resolution paleoclimatic simulations to define eco-cultural niches associated with Neanderthal and AMH adaptive systems during alternating cold and mild phases of Marine Isotope Stage 3. Our results indicate that Neanderthals and AMH exploited similar niches, and may have continued to do so in the absence of contact.
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The southerly contraction of Neanderthal range in southwestern Europe during Greenland Interstadial 8 was not due to climate change or a change in adaptation, but rather concurrent AMH [anatomically modern human] geographic expansion appears to have produced competition that led to Neanderthal extinction.
The main problem I've always had with "the climate did it!" explanations for megafaunal extinctions is that it isn't as if the climate didn't vary quite a bit across the Pleistocene. For example, the warmest phase of the Eemian interglacial 125,000 years ago saw forests in what is today tundra in northern Norway. So there was a different parameter on the scene more recently which did the big wildlife, including Neandertals. in....
More readable ScienceDaily summary....
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I don't buy the climate change extinction model either.
In historical timers the arrival of Europeans to long separated populations in the Americas or Australia resulted in the death of many of the original human inhabitants of these lands through new diseases carried there by the invaders. The separation of Neanderthal from Homo sapiens was probably an order of magnitude greater in terms of time and I suspect contact between the groups may have been fatal for our prominently eyebrowed cousins. The identification of DNA containing remains of some of these earlier out of Africa interlopers might throw some light on the mystery (perhaps look for the DNA sequences of specific pathogens they might have been carrying).
We ate them. Betcha.