Alien genetic architecture

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p-ter has a post up which he illustrates with a photograph of a rather ghoulish prosimian. I've read that some of the Victorians found chimpanzees & gorillas almost obscene because of their simultaneous resemblance to humanity and manifest inhumanity. I somewhat feel the same about prosimians, especially tarsiers. No doubt this is due to my relative familiarity with immature chimpanzees on television shows. In any case, there is a new paper out which demonstrates that the genetic architecture of blue eyes in two species of lemurs is not similar to that in humans. Contrast this to the case for horse and zebrafish.

A simple story could go that the specific character of a species' genetic architecture, the structure of relationships of genetic variation which contribute to the nature of a given trait, is purely a function of historical accidents, or, that there are widespread convergences across taxa. At least for pigmentation it looks to be a mix, which restrains us I suppose from making glib generalizations and inferences as to likelihoods. In the comments I wondered about Siamese cats, and the first author on the paper was kind enough to leave a comment:

Blue eyes in Siamese cats is likely due to a tyrosinase mutation: http://www3.interscience.wiley.c...652329/ abstract

[Well, that's proximate, Satan undoubtedly ultimate]

We did sequence this same HERC2 region for a few Burmese cats and Siberian huskies - they have the same conserved mammalian sequence.

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Last year a group out of Australia published a paper which purported to explain eye color variation based upon a polymorphism around the OCA2 locus. The paper was A Three-Single-Nucleotide Polymorphism Haplotype in Intron 1 of OCA2 Explains Most Human Eye-Color Variation, and I blogged it here.…
Sound familiar? Well, good things come in pairs. A few days ago I posted on a paper which used a linkage analysis to come to the conclusion that an SNP on HERC2 was responsible for the variation in eye color in Europeans. Some background, a gene, OCA2, was implicated in the variation in eye…
Via Dienekes, Interactions Between HERC2, OCA2 and MC1R May Influence Human Pigmentation Phenotype: Human pigmentation is a polygenic trait which may be shaped by different kinds of gene-gene interactions. Recent studies have revealed that interactive effects between HERC2 and OCA2 may be…
Richard Sturm in Human Molecular Genetics has a really good review of the current state of pigmentation genetics, with a human centric focus: The genetic basis underlying normal variation in the pigmentary traits of skin, hair and eye colour has been the subject of intense research directed at…

I want one.

By Sandgroper (not verified) on 12 Mar 2009 #permalink