The Dynamics of Deathly Drool (With BONUS LOL Komodo Dragons!)

Definitely breaking new ground around here. A recent paper in PLoS ONE examines the hypotheses surrounding the ecology and evolution of Komodo Dragon saliva. For those of you whose Komodo Dragonology is a little bit rusty, the saliva of Komodo Dragons can lead to infections that weaken or even kill prey that survive the original attack. Until this paper, there were two models to account for deadly drool:

1) Bacteria-as-venom model. The salivary bacteria are beneficial to the lizards, since they act as a de facto venom.

2) Passive acquisition model. Salivary bacteria are acquired from prey and the environment, and play no role in capturing prey. One piece of evidence for this hypothesis is that captive lizards in hygienic conditions lack salivary bacteria--very clean drool.

In this paper, the authors propose a third models: the lizard-lizard epidemic model. Before I get to the model, the data they present support the model, and don't contradict it, but more work needs to be done (the Komodo Dragon oral microbiome anyone?). The lizard-lizard epidemic model works like this:

1) Prey escape lizard attacks after being bitten. Of seventeen observed attacks, five survived being bitten. Here's one instance:

all ur nutrientz2
Original caption (mine is better!): Pursuit of an escaped prey by a second dragon. An injured Timor deer that has escaped an initial lizard has fled to the ocean and is being stalked by a different dragon. This second lizard succeeded in killing the deer. The Komodo dragon pictured is wearing a GPS collar used for tracking the animal. Occasional prey escape is essential to the operation of the lizard-lizard epidemic model.

2) Lizard bacteria cause an infection in tissues that are eaten by lizards.

3) Infected prey are EATED by other Komodo Dragons.

I haz a carcass

Original caption (mine is better!): Communal feeding illustrated. Three dragons are feeding on a wild pig. The large prey size of Komodo dragons with overlapping lizard home range generally precludes a single lizard from consuming its large prey alone. Multiple or shared feeding facilitates spread of infectious bacteria between lizard mouths.

4) Bacteria acquired from devoured prey colonize and reproduce in the lizard mouth.

Like I said, there's more work that needs to be done, such as characterizing the oral microbes, but it's interesting, if drooly, stuff.

Cited article: Bull JJ, Jessop TS, Whiteley M, 2010 Deathly Drool: Evolutionary and Ecological Basis of Septic Bacteria in Komodo Dragon Mouths. PLoS ONE 5(6): e11097. doi:10.1371/journal.pone.0011097

More like this

There are 29 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with…
For the longest time, people believed that the world's largest lizard, the Komodo dragon, killed its prey with a dirty mouth. Strands of rotting flesh trapped in its teeth harbour thriving colonies of bacteria and when the dragon bites an animal, these microbes flood into the wound and eventually…
[From the archives; originally posted November 22, 2005] Carl Zimmer has a post today about the work of Dr. Bryan Grieg Fry on the evolution of snake venom. If that name sounds familiar to those of you who aren't reptile specialists, you may have run across Dr. Fry's homepage, or you may have…
Now that seemingly the flu outbreak storyline has been wrapped up on The Walking Dead (unsurprisingly, but disappointingly, with their ineffective treatments proving to be miracle cures), there's still one more zombie microbiology topic I'd like to cover: what's up with the bite, and is it the…

This is indeed very interesting. I can definitely appreciate the "let's breed us some killer microbes in them bodies" approach. But that got me thinking! :)

First of all - if we're all so fascinated by Komodos' drooling, shouldn't we maybe catch us a dragon, obtain 50cc of drool/venom samples, sprinkle them on a bunch of stakes and go on an antelope stabbing spree? I guess that would solve the "is the saliva really THAT deadly" dilemma? Surely we're not above killing/maiming a bunch of game animals for the greater good?

Also, while we're @ venom - aren't Komodo bites supposed to be actually venomous now, rather than just septic? As in: venom dripping from venom sacs directly into bites. I remember reading something about a bunch of anti-coagulants and other wackadoodoos supposedly being produced by Komodos.

Why would lizards kept in hygienic conditions have clear drool? Lizard-lizard epidemic aside, shouldn't they grow an (un)healthy bacterial flora on the food residue in their mouths? Like humans? :)

Gee, the more I think about it, the more I go back to my first question - we can catch dragons easily, we do experiments on animals all the time, why are Komodos maintaining all this mystique? At least at first sight it appears that a year or two of serious work (feed, catch, collect, stab) should easily clear at least the basic uncertainties we have about this species.

On a lighter note: lolcats are a form of art ;). You may turn them into lolruses or loldragons or whatever, but you gotta stick to the form, man!

All ur nutrientz are BELONG to me!
and
You wantz sum?

Keep it real, as they say ;).

Have a great day,
MikeJ.

MikeJ,

In the paper they tested samples from various Komodos on mice to demonstrate lethality.