While historical accounts of the Spanish Hapsburgs dynasty have suggested that prevalent inbreeding likely contributed to the family's downfall, such suspicions weren't supported by genetic data--until now. In a new paper in PLoS One, researchers traced the genes of the Hapsburgs through more than 3,000 individuals over 16 generations to calculate the "inbreeding coefficient," a value that is highly correlated with genetic defects. The study found that much of the family's infertility could be explained by genetic defects propagated by first-cousin inbreeding.
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On November 1st, 1700, an entire dynasty of kings came to a crashing end with the death of Charles II of Spain. Charles had neither a pleasant life nor a successful reign. He was physically disabled, mentally retarded and disfigured. A large tongue made his speech difficult to understand, he was…
The Hapsburgs are one of those royal families who are relatively well known, and in the minds of the public are to a great extent the emblems of the downsides of inbreeding. To painting to the left is of Charles II, king of Spain, the last of the Spanish Hapsburgs, and an imbecile whose premature…
There are 9 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Connotea, Stumbleupon, Facebook and Digg) with just one…
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