Sonic hedgehog and Whales

i-ad09b8c822a0cb231c00b76717d7fdba-sonic.jpg What does Sonic Hedgehog on the left have to do with whale evolution? Nothing. However a soon-to-be-published study will argue that the gene Sonic Hedgehog (Shh) played a part. The abstract reads:

Among mammals, modern cetaceans (whales, dolphins, and porpoises) are unusual in the absence of hind limbs. However, cetacean embryos do initiate hind-limb bud development. In dolphins, the bud arrests and degenerates around the fifth gestational week. Initial limb outgrowth in amniotes is maintained by two signaling centers, the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA). Our data indicate that the cetacean hind-limb bud forms an AER and that this structure expresses Fgf8 initially, but that neither the AER nor Fgf8 expression is maintained. Moreover, Sonic hedgehog (Shh), which mediates the signaling activity of the ZPA, is absent from the dolphin hind-limb bud. We find that failure to establish a ZPA is associated with the absence of Hand2, an upstream regulator of Shh. Interpreting our results in the context of both the cetacean fossil record and the known functions of Shh suggests that reduction of Shh expression may have occurred ~41 million years ago and led to the loss of distal limb elements. The total loss of Shh expression may account for the further loss of hind-limb elements that occurred near the origin of the modern suborders of cetaceans ~34 million years ago. Integration of paleontological and developmental data suggests that hind-limb size was reduced by gradually operating microevolutionary changes. Long after locomotor function was totally lost, modulation of developmental control genes eliminated most of the hind-limb skeleton. Hence, macroevolutionary changes in gene expression did not drive the initial reduction in hind-limb size.

The paper is: J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, and W. E. Horton Jr. (2006) " Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan" PNAS published May 22, 2006, 10.1073/pnas.0602920103.

No doubt PZ will comment at some stage.

Update: PZ gives a great exposition of the paper here. (5/23)


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By John Lynch (not verified) on 22 May 2006 #permalink