biotechnology
sporte | January 2, 2009Mosquito-borne diseases, like Dengue and Malaria, are serious problems in many parts of the world. While some people are working on treatments for mosquito-carried disease, others are looking at ways to treat the mosquitoes.
Figure 1. Image of Aedes aegypti from the Public Health Library
tags: tropical disease, yellow fever, dengue, insect control,malaria
Controlling insect activities by messing with their genomes isn't a new idea. In many parts of the world, screwworms are controlled by damaging their genomes on a large scale by treating the flies with X-rays and releasing the…
sporte | December 29, 2008Cloning the gene for green fluorescent protein is fun. Lots of fun. Cloners have put the GFP gene into rabbits, plants, cats, fish, and worms, and made mutants that code for proteins in every color of the fluorescent rainbow. Teachers like GFP so much that every year, high school students throughout the U.S. clone GFP in biology class.
Now, some people, who call themselves DIY biologists, have started cloning GFP for fun in their kitchens. Other people find this alarming.
From Yahoo news:
Jim Thomas of ETC Group, a biotechnology watchdog organization, warned that synthetic organisms…
sporte | November 16, 2008Last spring, in a coffee shop in Berkeley, I saw an amazing thing. It was a cup made from corn. The information on the cup says that it is made from corn, is environmentally sustainable, and 100% compostable.
My fellow ScienceBloggers have written several articles lately about corn in fast food (here, here, and here), but I'm not sure they realized that corn is used for more than fast food. Corn is also used to make the packaging.
The company that made this cup is called Fabri-Kal. The cup is one of many compostable packaging items from Fabri-Kal's Greenware line. Interestingly, although…
sporte | November 13, 2008Well, I had to test Scribd with something. Why not use a document on the Massachusetts Life Sciences Industry?
Scribd is sort of like the YouTube of electronic paper. I found Scribd from TomJoe's post about Life on Mars. His PowerPoint talk is really much more interesting than the life science document that I uploaded as a test, but since you're here anyway, you might as well take a look.
What does Scribd do?
It solves the "waiting for another application to open" problem that I find so frustrating when I want to quickly read (okay, skim) a pdf document that's linked from something on…
sporte | November 12, 2008What skills does a biotechnology technician need to know?
This seems like a simple question, but people have been struggling to define biotech skill standards since the early 90's.
Complicating this question is that many areas of biotechnology require somewhat different skills. Antibody work requires one set, plant or animal tissue culture, another; fermentation, another; manufacturing, another; DNA sequencing, yet another set. Even skills that you might think are universal, like using a microscope, are not. During my years in graduate school, I never used a microscope; I cloned genes…
edyong | November 4, 2008
With current technology, could we clone a mammoth? Cloning techniques have made significant progress in recent years and at least one well-preserved specimen has been found. But the same freezing process that preserves the bodies of many extinct mammals would also be the undoing of cloning endeavours. Ice destroys cells, puncturing their membranes, bursting them and exposing their contents. Upon thawing, the dead cells would be useless as a basis for cloning.
Until now, the destructive power of ice seemed like an insurmountable obstacle, dashing the prospect of "resurrecting" frozen extinct…
sporte | October 25, 2008Why should professional scientists have all the fun?
Researchers have been engineering glowing cats, and selling glowing fish at pet stores. High school kids can do genetic engineering too, if they have the right equipment. And you can help them get the equipment by contributing to our DonorsChoose fund drive.
If you're willing to help students, they'll be able to do biotechnology in the class room and learn about DNA. They'll put genes for green fluorescent protein into bacteria and see how that bit of invisible liquid in a test tube gets used to make a glowing protein.
Even better,…
sporte | October 23, 2008This video from WDSU shows Mr. Green Genes, the transgenic kitty, in the dark and in the light.
There's also an interview with Dr. Betsy Dresser, who very briefly talks about the work at the Audubon Center for Research on Endangered Species.
Other than clips of the cat, and Dr. Dresser, the video mostly shows people taking frozen samples out of liquid nitrogen, but there's an interesting bit towards the end where they show a pipette transferring material into the nucleus of an egg cell. Mr. Green Genes is certainly a cute cat.
You can see more pictures from the Times Picayune: here and…
edyong | October 21, 2008
Fighting malaria with mosquitoes seems like an bizarrely ironic strategy but it's exactly what many scientists are trying to do. Malaria kills one to three million people every year, most of whom are children. Many strategies for controlling it naturally focus on ways of killing the mosquitoes that spread it, stopping them from biting humans, or getting rid of their breeding grounds.
But the mosquitoes themselves are not the real problem. They are merely carriers for the true cause of malaria - a parasite called Plasmodium. It suits neither mosquitoes nor humans to be infected with…
sporte | October 10, 2008The second speaker was Eric Davidson who talked about gene regulatory networks.
He works on sea urchins and showed us this amazing diagram that looked like a computer chip. The diagram describes the inputs and outputs of 50 genes during the first 30 hours of development.
And, it convinced me that systems biologists are developing their own language.
I've never heard gene expression described in these ways before.
Here were some of the phrases that Davidson used:
a set of boolean switches
a combination of double-negative regulation gates
feed forward regulation
using "AND logic"
boolean…
sporte | October 10, 2008The first talk was by Irving Weissman, one of the pioneers in immunology and stem cell research. He talked about the stem cells that form blood, also known as HSCs or hematopoietic stem cells.
These cells are great because they can self-renew, and they can divide and differentiate. That is, they can form new kinds of cells. Weissman talked about experiments that were done at different companies, Systemix, Cellerant, Inc., and others with using stem cells to see if certain types of disease could be cured (in mice) by repopulating the mice with new stem cells.
Some interesting things -
-…
sporte | October 10, 2008Right now, I'm sitting in the audience at a symposium on Science, Engineering, and Business at the Leading edge. The symposium is sponsored by the Institute for Systems Biology and it's Lee Hood's 70th birthday. Every speaker is beginning with a wish for a happy birthday.
I'll have updates, as I can, throughout the day.
sporte | October 10, 2008Sometimes words fail me. Luckily, we have videos.
Many of you have probably read about Roger Tsien receiving the Nobel Prize this work for his work with the green fluorescent protein (GFP), but I bet some of you are wondering, why a jellyfish protein is worth a Noble Prize.
I think one of the best places to see why GFP is important, and also to see what some scientists do during the day, is JOVE, the Journal of Visualized Experiments.
The wonderful video, that's shown in this image, describes a new method for investigating Parkinson's disease. This is the kind of biological work that we…
sporte | October 8, 2008Over the years, I've seen many biotechnology education programs at community colleges embrace outreach to high schools as part of their mission. This kind of enthusiasm for outreach seems unique to biotech. No other kind of science or engineering program seems to do this sort of thing, at least not on the nationwide basis that I've seen demonstrated in biotechnology.
And yet, even though I've always admired and often participated in these efforts, some aspects are a little puzzling.
How do the colleges reconcile the energy spent in outreach efforts with the energy spent towards educating…
sporte | October 4, 2008Long Branch, NJ, is a lovely town on the Atlantic Ocean, with long beaches and brand new shops and condos. It is also part of an area in, central New Jersey, where biotechnology education is entering an exciting time thanks to efforts of NJBEC, Bio-1, and a WIRED grant from the U.S. Department of Labor.
NJBEC, Bio-1, WIRED? What do all these acronyms mean?
I get these things confused all the time, so I'll take a quick moment and explain.
NJBEC is the New Jersey Biotechnology Educators Consortium. Bio-1 is a partnership between five counties and several schools in central New Jersey, that…
sporte | October 1, 2008ScienceBlogs and science bloggers, in general, have enthusiastically supported fund-raising efforts by DonorsChoose for the past two years, and we're doing it once again for 2008.
DonorsChoose works like this: teachers write descriptions of what they want and how they'll use it for teaching, and submit their proposals to DonorsChoose. We pick the projects we like and if you like them, too, you can help get these projects funded.Donate to schools! Win a prize!
Last time I did this, we ended up funding three cool projects in biotechnology education. Students in Mrs. G's classroom in South…
edyong | October 1, 2008
The world is currently home to 6.5 billion people and over the next 50 years, this number is set to grow by 50%. With this massive planetary overcrowding, Band Aid's plea to feed the world seems increasingly unlikely. Current food crops seem unequal to the task, but scientists at Texas University may have developed a solution, a secret ace up our sleeves - cotton.
Cotton is famed for its use in clothes-making and has been grown for this purpose for over seven millennia. We do not think of it as a potential source of food, and for good reason. The seeds of the cotton plant are rife with a…
sporte | September 30, 2008I learned via e-mail yesterday that the biotechnology program, that I taught with for ten years during the 90's, is ending due to low enrollments.
I also learned yesterday, via the Seattle Times, that a resurrected version of ICOS called CMC Icos Biologics is planning a $35M expansion of their biotech manufacturing plant in Bothell and talking about hiring lots of students with two-year degrees.
The irony isn't lost on me.
We struggled with variable enrollments too, when I was at Seattle Central Community College. A couple of years saw way too many students and troubles finding enough…
sporte | September 29, 2008This First Annual Conference for New Jersey Biotechnology Educators will be held on Saturday, Oct. 4th at Monmouth University in West Long Branch, New Jersey.
I'm excited about attending this conference, not only because of the biotechnology part, but because I've reading Sarah Vowel's book Assassination vacation and I'm looking forward to seeing the last resting place of President James Garfield. Sarah Vowel is an incredibly funny commentator on NPR's "This American Life" and so, even though I don't usually read about people making pilgrimages to famous presidential sites, I had to read…
terrasig | September 24, 2008Any of you working in academic programs that offer forensic sciences training are well aware that CSI has been a boon this multidisciplinary area of biology, chemistry, engineering and materials sciences.
However, we don't yet have any television programs glorifying a career in pharmacology or biotechnology.
I've just spent a few hours on YouTube, BSCS, Bio-Rad, and a bunch of other science education sites but I can't find what I am looking for.
What I need: A 10-12 minute video for high school students that demonstrates career opportunities in biotechnology and/or the biologicals side of…