clinical trial
oracknows | November 4, 2012Chelation therapy, in my somewhat Insolent opinion, is pure quackery. Unfortunately, it's also one of the most common quackeries out there, used by a wide variety of practitioners for a wide variety of ailments blamed on "heavy metal toxicity." Chelation therapy involves using chemicals that can bind to the metal ions and allow them to be excreted by the kidneys is standard therapy for certain types of acute heavy metal poisoning, such as iron overload due to transfusion, aluminum overload due to hemodialysis, copper toxicity due to Wilson's disease, acute heavy metal toxicity, and a handful…
oracknows | September 11, 2012I sense a disturbance in the skeptical blogosphere. It is something that I half-expected, but, even so, it nonetheless somewhat surprised me when it arrived in the form of comments on my blog and e-mails from readers, fellow supporters of science-based medicine, and others asking me what I thought. In a way, it makes me glad that I didn't blog about this back on Monday, when the study that is the focus of this disturbance was published. Had I written about it then, all I would have had as fodder was the study itself. However, waiting a couple of days has allowed me to see the reaction of the…
ddobbs | March 5, 2009Philip Dawdy takes a interesting look at a new study of the safety of placebo arms in clinical trials of antidepressants in teens. My own quick scan of the study [which Dawdy makes available as pdf download] suggests it's full of great nuggets.
Its take-home: Placebo treatments produced remission rates of 48%, while the rate for active treatment was 59%. And, quite interestingly, the study concludes:
Patients who responded to placebo generally retained their response. Those who did not respond to placebo subsequently responded to active treatment at the same rates as those initiallyl…
ddobbs | February 26, 2008[This is a revised, expanded version of the original heads-up I put up last night.]
A large new meta-analysis of SSRI antidepressant trials concludes that the drugs have essentially no therapeutic effect at all. The study, in PLOS Medicine today, comes on the heels of another study published a few weeks ago (I blogged on it here) showing that SSRIs have little therapeutic effect if you include the (unflattering) clinical trials the industry had previously hidden.
The PLOS study is a meta-analysis of 47 clinical trials that account for almost all full data on clinical trials of SSRIs such as…