drugs of abuse
terrasig | July 13, 2010In remarking Sunday on coverage of the synthetic marijuana products in The New York Times, I totally missed that a more detailed article appeared the day before in The Washington Post.
With contributions from Aaron C. Davis, the article by writer Michael W. Savage provided an insight into Spice use in Adams Morgan and around the District. The second page of the online article goes into much more detail than the NYT article by addressing the pros and cons of state approaches to outlaw the compounds and products.
Savage also included commentary by Marilyn Huestis, chief of chemistry and drug…
terrasig | July 11, 2010Overnight, Malcolm Gay posted an article that appears in this morning's Sunday edition of The New York Times regarding synthetic marijuana products.
"Incense" blends such as K2, Spice, Black Mamba, and Wildfire Extreme are sold legally in most states in the US but have been illegal in Europe for over a year. These herbacious products are sprayed with one or more compounds originally synthesized in the laboratory of Dr. John W. Huffman at Clemson University. The compounds carry his initials followed by a number, such as JWH-018. The chemical structure of the compounds are different from the…
terrasig | July 8, 2010Toxicity reports are re-emerging in southern California this week after a dozen hospitalizations of kids using teas made from a fragrant flowering plant called Angel's Trumpet. A tea made from the plants is used to produce hallucinations, but they can progress to extremely unpleasant experiences. Moreover, Angel's Trumpet can be deadly, accelerating the heart rate and causing fatal cardiac rhythmic disturbances and bronchoconstriction that can trigger asthma attacks in sensitive individuals.
Angel's Trumpet is one of a series of plants in the Brugmansia genus that make a variety of muscarinic…
terrasig | July 3, 2010The 75th anniversary of Alcoholics Anonymous has brought out a spate of legacy media articles about the organization, most singing the praises of an unscientific movement begun during The Great Depression that still forms the basis of many clinical drug and alcohol addiction treatment programs.
My post Thursday on Brendan Koerner's Wired article brought out a very thoughtful commenter and sharp writer, friendthegirl. I learned that ftg writes the blog, Stinkin' Thinkin': Muckraking the 12-Step Industry.
Stinkin' Thinkin' was started with the intention highlighting the quackery and abuse that…
terrasig | July 1, 2010The last two days (here and here), you lovely commenters and I have been bantering about legacy media's reluctance to use the original literature citation in print or online coverage of science, medicine, and health stories. The discussion has drawn input from working writers as well as scientists and bloggers and I also draw your attention to the comments at the impetus for these posts over at The White Coat Underground with PalMD.
But remember, my dear ink- and pixel-stained friends, I am also a graduate advisory board member and instructor in a science and medical journalism program at a…
terrasig | May 25, 2010Just a quick post this morning as I am performing my professional responsibility to our nation's health research agency.
In yesterday's issue of USA Today (which I only read on the iPhone app or when staying at a hotel that gives it to us free), Donna Leinwand wrote about a currently legal substitute for marijuana called by various names such as K2, Spice, Black Mamba.
Nearly a dozen states and several cities are banning or debating bans on K2 -- a packet of herbs coated with a synthetic chemical that mimics a marijuana high when it's smoked -- amid fears that its use is spreading among young…
terrasig | April 10, 2010Last July we wrote about the 40th anniversary of the Apollo 11 moon landing and spoke of Buzz Aldrin's autobiography about his battle with alcoholism in the years following. The post drew a comment from a reader who I've renamed "Anon."
Thank you so much for this post.
I am a recovering drug addict and am in the process of applying to graduate programs. I have a stellar GPA, have assisted as an undergraduate TA, and have been engaged in research for over a year.
I also have felony and was homeless for 3 years.
I don't hide my recovery from people once I know them, but I sometimes, especially…
terrasig | March 11, 2010This is a repost of my reflections on my father who passed away 13 years today. It took me 12 years to write the following eulogy and remembrance. While quite personal, I posted it here last year because I felt that my experiences were quite universal, shared by the families of the ten or twenty million alcoholics in the US and the hundreds of millions worldwide. Moreover, I wanted to provide a face for my colleagues who work in the area of substance abuse and a reminder for my clinical colleagues of the people behind those they may dismiss as drunks and junkies.
In becoming one my most most…
terrasig | February 19, 2010Just a quick post on an article that caught my eye: Jazz Pharmaceuticals of Palo Alto, CA, has announced that the US FDA has accepted their new drug application (NDA) filing for JZP-6, or sodium oxybate, for the treatment of pain and fatigue associated with fibromyalgia.
The NDA was based on positive outcomes of two, Phase III clinical trials - those randomized, placebo-controlled double-blind trials that serve as the gold standard for drug efficacy. The company expects an approval decision from FDA by October 2010.
Jazz has already garnered approval for sodium oxybate under the brand name…
terrasig | February 9, 2010Thank you for visiting our introductory post on K2 Spice and welcome readers from Maia Szalavitz at the TIME Healthland blog. The comments to which she refers can be seen by scrolling to the end of the post.
However, our blog has moved since this was posted in Feb 2010 and any further comments are closed. But if you wish to share any experiences and participate in further discussion, please visit us at our new home here.
If you're interested in our other posts on K2 Spice or other legal highs, click here.
Finally, if you're interested in our comments on Purdue University chemist and…
terrasig | January 14, 2010Hearty congratulations this morning to a group of early-career investigators who received this award yesterday in Washington, DC:
The Presidential Award for Early Career Scientists and Engineers was established in 1996 and is the highest honor bestowed by the U.S. government on outstanding scientists and engineers beginning their independent careers. [emphasis mine] Awardees are selected on the basis of two criteria: pursuit of innovative research at the frontiers of science and technology; and a commitment to community service as demonstrated through scientific leadership, public education…
terrasig | December 23, 2009On December 14 (last week), the US National Institute on Drug Abuse (NIDA) released the findings on adolescent drug use and trends as determined from the 35th annual Monitoring the Future (MTF) survey (press release). The ambitious survey is conducted with NIDA funding* by the University of Michigan's Institute for Social Sciences led currently by Dr. Lloyd Johnston. The larger survey began in 1975 with only high-school seniors and was expanded in 1991 to include 8th and 10th graders to improve the ability to measure changes as a population progresses through school. A very detailed white…
terrasig | December 14, 2009Update: New ScienceBlogs colleague, Sharon Astyk at Casaubon's Book, brought my attention to the fact that this local southern Colorado story has been picked up by CNN.
Although I originally wrote this post rather tongue-in-cheek, some scientific evidence has accumulated for the benefits of cannabis in neuropathic pain, cancer pain and nausea, as well as muscle spasticity in multiple sclerosis. For what appears to be a subset of individuals, marijuana is superior to prescription drugs in terms of efficacy and side effect profile. Equivocal results with a standardized cannabis extract…
terrasig | December 9, 2009By way of my substance abuse blogger colleague, The Discovering Alcoholic, I learned of yesterday's New York Times article by Sarah Kershaw on Dr. A. Thomas McLellan. McLellan is a psychologist and drug abuse researcher with over 400 peer-reviewed publications to his credit. He held an academic appointment at the University of Pennsylvania School of Medicine and was scientific director of the Treatment Research Institute which he co-founded in 1992 with Jack Durell, MD, and other researchers from Penn's Center for the Studies of Addiction.
However, McLellan is not a career bureaucrat like…
terrasig | November 10, 2009I missed this note on Friday at the Wall Street Journal Health Blog but the National Institute on Drug Abuse (NIDA) has made available some great new curricular resources through their Centers of Excellence for Physician Information Program (NIDA CoEs) (press release)
"Physicians can be the first line of defense against substance abuse and addiction, but they need the resources and the training," said NIDA Director Dr. Nora D. Volkow. "Our long term goal is for doctors to incorporate screening for drug use into routine practice like they currently screen for other diseases; to help patients…
terrasig | August 31, 2009
The Boulder County coroner announced today that the July death of a Boulder teen was indeed due to opioid intoxication from preparation of a poppy pod tea.
Jeffrey Joseph Bohan, 19, of Boulder, was found dead in his friend's Boulder home about 6 p.m. July 21 after drinking poppy-pod tea the night before with his brother, according to Boulder police.
Investigators suspected the Fairview High graduate, who was going to Colorado State University, died from the psychoactive tea, which is brewed from the plant that produces opium. But they couldn't be sure until the Coroner's Office confirmed…
terrasig | August 24, 2009
Propofol.
For further information and detailed background, please see our previous post on this injectable anesthetic agent known as propofol or Diprivan®.
This L.A. Times article today also has a concise timeline of the events leading to the death of Michael Jackson
terrasig | July 28, 2009[This 23rd July entry is being reposted today under the ScienceBlogs "Education" channel as its original categorization there fell victim to gremlins in the upgraded Movable Type script.]
At the outset, let me say that I have immense respect and admiration for a special commenter.
In last week's Friday Fermentable post, we took the 40th anniversary of the Apollo XI mission as an opportunity to draw attention to Buzz Aldrin's newly-released autobiography, Magnificent Desolation. In it, Aldrin describes his lifelong battle with depression and alcoholism and how he has managed both challenges.…
terrasig | July 17, 2009Please accept my apologies in advance for taking another edition of The Friday Fermentable to bring you a sober (pun intended) story about alcoholic beverages. The heat, beginning training for a half-marathon, and other stuff have my personal alcohol consumption at nil so I don't have any recent wine or beer finds to share with you, Dear Reader.
Moreover, there have been some prominent stories as of late relating to alcohol and substance abuse such as the pharmacology and toxicology of Michael Jackson's death (which we've discussed here, here, and here) and the prevalence of alcoholism in…
terrasig | July 7, 2009While invoking my little-known real name, the ABC News Medical Unit shows its commitment to providing scientifically-objective and medically-valid commentary to the Michael Jackson circus.
The post cited was from 26 June where I discussed the first Michael Jackson revelation that he had repeatedly been given the unusual opioid drug, meperidine, presumably for his chronic back pain.
From this morning's ABC News story by Vic Walter and Richard Esposito with contributions from JoAnna Schaffhausen:
One pharmacologist blogged about [p]ropofol this week and explained in his science blog how Demerol…