Historical studies of disease
tsmith | January 27, 2006Speaking of chronic diseases caused by microbial agents, one of the earliest characterized of these is the group A streptococcus (Streptococcus pyogenes). In addition to causing acute diseases such as strep throat and scarlet fever, a wide range of post-infectious sequelae (complications that appear following resolution of infection) have been attributed to S. pyogenes. It can cause glomerulonephritis, a kidney disease. It's long been known infection with the organism can lead to a condition called Sydenham's chorea, a neurologic disease characterized by jerky movements. Infection with S…
tsmith | January 25, 2006Day 1: History of Pandemic Influenza.
Day 2: Our adventures with avian flu.
Day 3: Challenges to pandemic preparedness
Day 4: 1918 influenza virus reconstructed
Day 5: How ready are we, and what can YOU do?
Many more influenza posts can be found at this link.
tsmith | January 24, 2006It seems I may have spoken too soon. Quoting myself:
One historical event that has been the subject of much speculation over the decades has been the Plague of Athens, a mysterious outbreak that is thought to have changed the direction of the Peloponnesian War, and for which the cause still remains uncertain.
This plague has been attributed to bubonic plague, toxic shock syndrome and/or necrotizing fasciitis due to Streptococcus pyogenes or Staphylococcus aureus, Salmonella, yellow fever, malaria, Ebola, influenza, and smallpox, to name just a few. Typhus seems to fit the description…
tsmith | January 20, 2006I'm late to the party, but Chad over at Uncertain Principles put out a call for great experiments/observations in our fields. Like others have said, that's a tough one, so I thought I'd first run through some of the highlights and big breakthroughs in the fields of microbiology and infectious disease epidemiology that have made the field what it is today, and then end with the one I think is most important. Feel free to disagree.
Obviously, several early advances stand out that allowed for the field to really start to develop. In roughly chronological order:
Antony van…
tsmith | January 12, 2006I'm still working on finishing up 3 manuscripts (one book, 2 journal articles) so I've not blogged quite as much this week as I generally do. Next week I should be back up to speed, and have a few topics in the queue that I want to get to. Luckily for you, though, John Hawks has a pair of excellent posts discussing infectious disease issues, Sciencblogs neighbor RPM at Evolgen has a post on microbial diversity, and fellow PT contributor Mike Dunford has a post discussing the CCR5 deta 32 mutation, HIV resistance, and West Nile over at The Questionable Authority. Discussion of these and a…
tsmith | December 16, 2005 I love these historical analyses of disease--real, or fictional. One historical event that has been the subject of much speculation over the decades has been the Plague of Athens, a mysterious outbreak that is thought to have changed the direction of the Peloponnesian War, and for which the cause still remains uncertain:
[2] As a rule, however, there was no ostensible cause; but people in good health were all of a sudden attacked by violent heats in the head, and redness and inflammation in the eyes, the inward parts, such as the throat or tongue, becoming bloody and emitting an unnatural…
tsmith | October 6, 2005I know I said I was going to discuss a bit more about pandemic preparedness today, but I think I'll hold off on that to discuss this story:
It sounds like a sci-fi thriller. For the first time, scientists have made from scratch the Spanish flu virus that killed millions of people in 1918.
Why? To help them understand how to better fend off a future global epidemic from the bird flu spreading in Southeast Asia.
Researchers believe their work offers proof the 1918 flu originated in birds, and provides insights into how it attacked and multiplied in humans. On top of that, this marks the first…
tsmith | October 3, 2005It's hard to avoid hearing about influenza virus these days. In all the noise, it's tough to sort out the facts from the rumors and conspiracy theories. I've already discussed a bit about the basic biology of the virus in this post, so I'm not going to review that here (though a good overview can be found here for those of you who need to bone up on your influenza virus biology). So, this week, as a part of Pandemic influenza awareness week, I'll be writing a 5-part series about various issues regarding influenza. Today, I'll discuss the history of influenza, focusing on past pandemics. The…