lung
dr. dolittle | March 16, 2014 Figure 1 showing RAGE (aka: Ager) expression only in mammals from Sessa et al., PLOS ONE. 9(1): e86903, 2014.
RAGE stands for "receptor for advanced glycation end-products", also known as "AGER", and new research shows that it first appeared in mammals (Sessa et al., 2014). Despite the name, the receptor also binds other signaling molecules such as HMGB1, S100 proteins, beta-amyloid, phosphatidylserine, among others (Xie et al., 2013). RAGE is reportedly involved in diabetes, cardiovascular disease, atherosclerosis, osteoarthritis, cancer, Alzheimer's disease, as well as liver and renal…
dr. dolittle | February 25, 2014Congratulations to Nicolle Domnik, this year's winner of the new Dr. Dolittle Travel Award to present her research at the annual Experimental Biology conference in San Diego, CA in April. Nicolle is currently a graduate student in the Department of Biomedical and Molecular Sciences at Queen's University in Canada. The award criteria included the submission of a guest blog entry based on the research she will be presenting at the Experimental Biology conference (N Domnik, SG Vincent, E Cutz, JT Fisher. Murine airway slowly-adapting receptor responses to lung inflation: A role for serotonin?…