The transcript is degraded, but a new one is synthesized

A brief history of my life as a blogger.

I started about a year ago. Then being plagued by creationist ads, I moved my blog from Tripod to Blogspot. Everything was fine until (as one person later said) I was Degoogled. Finally after being invited to move to Scienceblogs, I ditched my old blog and ...

here I am.

Think of this blog as a daily "water cooler chat" with a Cell Biologist.

The focus of my current research is mRNA, the product of activated genes that is used as a template for protein production. Since mRNAs are copied from genes, they're known as transcripts, and hence the title of my blog. Another focus of my work is the endoplasmic reticulum, a network of membranous tubes and sheets (pic on the right) where certain mRNAs are translated to membrane-bound and secreted proteins. Like all crazed scientists who can't stop talking about their obsessions, these topics will pop up in many posts. Also of note, I was trained in the "cytoskeletal field", or the study of proteins that are responsible for shaping and organizing the cell. Thus you'll find many entries on actin, microtubules (pic on the right) and focal adhesions. I guess the gestalt of my scientific career is "how life is organized on the cellular level".

But this blog, just like Seed Magazine, is not just about science. I'll be posting on art, food, city life and other mental stimuli.

Later I'll try to post a "best of" my previous blogs.

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Last week I saw an awesome lecture by Gaudenz Danuser who has a lab at the Scripps institute in San Diego. It has taken me a week to fully digest what was said, plus I haven't had the time to jot this down. Over the past few years the Danuser lab along with Claire Waterman-Storer's group (see this…
Well in a previous entry I wrote: Generally, prokaryotes are devoid of membrane-bound organelles (including the nucleus, mitochondria, the endoplasmic reticulum), and their cytoskeletal systems are quite simple. And I got a comment about magnetosomes, small membrane bound organelles found in…
OK today I'll talk about yet another paper from Jonathan Weissman's group at UCSF ... but I'll write it up in two parts. This post will be generally background about the ER and its ability to degrade proteins. When many scientists think about "cellular functions", diagrams of the central dogma of…
I just read a fascinating "hypothesis" in the latest issue of Nature entitled Introns and the origin of nucleus cytosol compartmentalization. The greatest divide in the living world exists between prokaryotes and eukaryotes (yes I know, there are viruses ... but lets not get off topic!). Generally…

Congratulations on the upgrade!

we slothenly blogspot bloggers will miss you.

sniff...

May the road rise to meet you.
May the wind be always at your back.
May the sun shine warm upon your face.
And rains fall soft upon your fields.
And until we meet again,
May TFSM rain moles of RNases down on your
competitors and any jerk reviewer
who gives a thumbs down, or for that
matter even asks for more experiments
(you know who you are you losers!)

Welcome to the bloghood. I'm a cell bio/biochemist as well, looking forward to some god ol' down home RNA talk.

Wow the new site looks great, hope you'll post more pictures.

By Acme Scientist (not verified) on 02 Mar 2006 #permalink

Sorry that the comments didn't pop up when you all posted them, I'm struggling to get everything in working order. But I'm getting there.

Thanks for the encouragement BC.

Dr. Free Ride and Razib - hope I can blog up to your standards.

Dior AAU UCG ACC UAA (had to end on a stop codon).

Acme, nice to see that you're in a positive mood!

I am curious about the Er picture. You mention two pics and I recognize the microtubule pic... Is the ER green and the microtubule red in the same image? If so, what cell type is that?

By Marguerite McDonald (not verified) on 01 Oct 2008 #permalink