I must say that the animators omitted many details, such as the RNA polymerase's c-terminal repeats, splicing, the assembly of an RNP, the workings of the nuclear pore complex, and the assembly of a translation initiation complex ... but WOW! We need more of these videos!
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Earlier today I gave our weekly journal club. As usual there is some large scheme/model/godzilla image associated with the intro/summary. Here's mine ... mRNA nuclear export in yeast:
Highlighted are 3 major systems. Many proteins are listed, many more are not.
Nucleoplasm is on the bottom,…
Recently there has been a flood of press about epigenetics and non-coding RNA. What is lacking from these articles is a description of how DNA is packaged and what DNA elements such as promoters and enhancers do. Today I would like to touch upon all of these subjects with a post on how DNA is…
Replication fork - http://en.wikipedia.org/wiki/Telomere.
Organisms with linear chromosomes have to solve the problem that DNA replication makes them shorter. This is due to the fact that DNA polymerase can only add bases to the terminal 3'-OH of a DNA chain. The DNA replication initiation…
I've been struggling with eIF4E. You see eIF4E is the major cytosolic cap binding complex. When mRNA is synthesized in the nucleus the cap is loaded with nuclear cap binding complex, CBP80/20. Then (the story goes) the mRNA is exported to the cytoplasm where the ribosome engages the transcript and…
That animation was done, form the primary literature, by Drew Berry at the Walter and Eliza Hall Institute. At the time, he was my staff member. You can find more of Drew's animations here.
Ya, EXPELLED maggots stole this animation for their oh-so-secret private showings and PR material too. Specifically, the DNA-->mRNA step.
Funny thing, synchronicity. I saw one of Drew's fantastic videos at a talk a couple of weeks ago. Been meaning to blog about it ever since :)
What is this background noise? The sound of DNA, folding ?