Loss of a giant: Joshua Lederberg

Joshua Lederberg passed away on Saturday.

Joshua Lederberg, Nobel Prize-winning molecular biologist who shaped the field of bacterial genetics, and served as chair of The Scientist's advisory board since 1986, died on Saturday (February 2). He was 82.

Lederberg shared a Nobel Prize in physiology and medicine in 1958 for the discovery that certain strains of bacteria reproduce by mating, thereby exchanging their genetic material. This overturned the idea held at the time that bacteria did not warrant genetic study and set the field of bacterial genetics into motion.

Lederberg truly was a visionary, and along with his ex-wife, Esther (who died just over a year ago), really jump-started the field of microbial genetics (and indeed, made it much easier to study genetics, period), winning a Nobel prize for his genetic work when he was only 33. Years later, he teamed up with Carl Sagan to raise awareness about microbes in space, and was an advocate of science communication and sound policy (serving as an advisor for multiple presidents). In recent years, he's spoken out about antibiotic resistance and bioterrorism, among other topics, and always emphasized the importance of basic research in microbiology. He could also give a helluva interesting talk, judging from the few times I've seen him speak. He was truly a living legend, and the void he leaves is palpable.

More info and access to papers at the here at the National Library of Medicine. Image from http://www.columbia.edu/cu/21stC/issue-1.1/prof2.gif.


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Via Tara Smith, I learned of the passing of Joshua Lederberg. I came to appreciate the full scope of Lederberg's work while working on my book Microcosm; by discovering the secret sex life of E. coli, he helped build the science of molecular biology. It's sad to observe the passing of this…

He was pals with Carl Sagan, who was married to Lynn Margulis, who denies hiv's causal role in AIDS and claims 9/11 was an inside job. So he is closely associated with crankery and his degree of crankery should be investigated, and if an crankery is discovered we should all get together and say "woo woo" in ritualistic fashion, "woo woo" repeatedly and say "crank" over and over again. This would give me a total boner.

"News at 11, the Worlds leading professional science Journalist "Cooler" brilliantly satirizes Seeds Scientists in a mindshaking post."

Crankish satire aside... Apart from his social life, Lederberg was the real deal; an original thinker who pushed those around him to see the world from unexpected vantage points. We need more Lederbergs.

By bob koepp (not verified) on 05 Feb 2008 #permalink

Sagan divorced Lynn Margulis and married Linda Salzman in 1968. Lederberg divorced and remarried at about the same time. Coincidence?