Using HSV-1 to 'cure' rhabdomyosarcoma? *fingers crossed*

WARNING: Get a box of Kleenex before you read this post! I am NOT joking.

A few weeks ago I wrote a post on how scientists are using a genetically modified herpes simplex-1 virus to attack metastatic melanoma (an oncolytic, ie kills tumor cells, virus). The results of their clinical trials blew my mind.

Today I found out (thanks to an awesome reader!), that they are trying a similar protocol in a 13 year old kid with rhabdomyosarcoma. What this boy has been through:

Now 13-years-old, Evan was diagnosed with rhabdomyosarcoma in June 2008 at the age of 11...
... He's endured 28 rounds of radiation, and 52-weeks of a phase III chemotherapy protocol. After a brief three-month remission, the cancer returned in December 2009. Since then Evan has undergone several months of a phase II chemo, a phase I chemo trial in St. Louis, and made history by becoming the first participant in a phase I virus trial in Cincinnati.

Holy crap.

The tumor is in his brain, so heres what they had to do to get the genetically modified HSV-1 into it:

As Steve posted, yesterday's procedure went exactly as planned. The interventional radiology team inserted a long, thin needle through Evan's right cheek, maneuvering through bones, blood vessels, etc. to reach the tumor in his head. They chose an area that showed a large amount of cancerous activity on the scans and injected the virus, pulled back on the needle and released more virus into a second nearby location.
...Evan had quite a bit of pain throughout the night, but the medical team here has been excellent and very responsive to his needs. He's resting comfortably now and if his pain stays managed we'll be discharged and return to our hotel later today.

Shiiiiiit...

May the Force be with you, kid.

Categories

More like this

WHOOOOOOOO!!!! April 7, 2010: Using HSV-1 to cure metastatic melanoma May 26, 2015: Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma WHOOOOOOOOOOOOOOOO!!!!! They just published the results of Phase III clinical trials of a herpes simplex-1 genetically…
Hey remember how I told you all scientists are using herpes, the regular-ol much hated cold-sore virus, to treat/cure cancers? The approach has left us with miraculous effects... or no effects at all. I mean, half of the melanoma patients lived A LOT LONGER than they were supposed to, several of…
Metastatic melanoma is definately one of the Cancers That Suck. We basically have the same treatment options in 2010 as they had back in 1975... and not because we have chemotherapy/immunotherapy that works super great, no reason to change it. Our treatment options just suck, with horrible…
This is one of the cool ideas not included in the 1800 human gene therapy trials because its still in animal models, not humans: Preclinical Therapy of Disseminated HER-2+ Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus If Ive said it once, Ive said it 1000 times: '…

How cool is it to see viruses being used to bring HOPE to people? :)

I also like that I haven't seen signs of woo in the family's blog...just a whole lotta prayin'. I'll take that over some Hoxsey scammer any day.

One of our friends had an eleven year old with diffuse intrinsic pontine glioma. They buried him about ten months ago.

I was okay until I watched the "thank you" video on Evan's site.

28 rounds of radiation?

ugh.

By Prometheus (not verified) on 07 May 2010 #permalink

Holy F^@K! That's too much to ask of a kid. I wish him all the best.

I can only hope to be that brave should I or anyone close to me be in a similar situation.

Wow. Go dude!

inserted a long, thin needle through Evan's right cheek, maneuvering through bones, blood vessels, etc.

Ouch.

I guess this is one of those "the Lord works in mysterious ways" things, right?

In the 60s, a dermatologist tried an experimental protocol using smallpox vaccine to innoculate a large restrictive wart on my right thumb. Scabbed up and healed nicely, never to return. Apparently, the research didn't pan out to make this a standard treatment because I've never heard of anyone else having this done. Yes, having the science to harness a devastating virus for good is an incredible feat. We live in a marvelous era. May Evan live to see even more fantastic times.

Unfortunately the family is reporting the therapy isn't working, and he's returned home to a Springfield hospital by helicopter. :(

I pray that Evan and family are doing as best they can. May love and God be with you. My 13 yr old girl Rachel fought Rhabdomyosarcoma for 2 years. Rachel lost that fight in January 2010. I pray the cure will soon be found. Unfortunately my sadness will remain with me.

my daughter was diagnosed with rhabdomyosarcoma alvelor
she relasped after 5 weeks off chemo in the brain
had it surgically removed then she did 20 days of radiation
We found out that she has possible tumors in the pelvic right side bones we will know more tommorow.
They want to put her on a low dose chemo and now we have to pray
will this hsv-1 help my daughter please let me know where i can do this trial and if this will help her

By dorit mordehay (not verified) on 13 Jan 2011 #permalink