A current study in Science from the Tokyo Institute of Technology seems to demonstrate how Thalidomide causes birth defects. Here's the abstract from the paper:
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still used in the treatment of leprosy and multiple myeloma, although how it causes limb malformation and other developmental defects is unknown. Here, we identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin ligase activity. This study reveals a basis for thalidomide teratogenicity and may contribute to the development of new thalidomide derivatives without teratogenic activity.
Source:
Ito et al 2010. Identification of a Primary Target of Thalidomide Teratogenicity. Science. Vol. 327. no. 5971, pp. 1345 - 1350. Link
More like this
The story of thalidomide, the notorious teratogenic drug developed in Germany and sold around the world from 1957 to 1961 as a treatment for morning sickness, continues to unfol
Earlier this week, FDA Commissioner Margaret Hamburg presented Frances Kelsey with the first in what will be a series of awards bearing Kelsey's name.
--Widely considered the founder of modern-day Pediatric Cardiology
--Discovered the cause of “Blue Baby Syndrome” in infants, and helped ban the use of the drug Thalidomide for pregnant women in the U.S.
I learned over the weekend that a historic figure in science-based medicine has died. If you know anything about the history of the Food and Drug Administration (FDA), you will know this woman's name, Frances O. Kelsey, MD, PhD. It turns out that Dr.
Maybe. But thalidomide interferes with NO signaling too.
http://www.ncbi.nlm.nih.gov/pubmed/19912234
I suspect that is how thalidomide causes autism in a very narrow time window.
Birth defects occur during fetal development. Most of them appear in the first trimester and alter the aspect and the functionality of the body. Various organs are affected( brain and head malformations, heart, lungs, liver, digestive system) and also bones.