A few months ago, a group published a report that this polyamine was an effective quadruplex ligand, inducing senescence of cancer cells.
It's perhaps unsurprising that this works. I've previously covered Telomestatin (more selective) and TMPyP4 (less selective), but man, just a big charged chain of stuff? Apparently, though, this molecule is used in vivo already, in chelating copper ions in the treatment of Wilson's disease.
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As many estimable colleagues have noted, guanine's weird. It's not that soluble, which isn't too much of a problem when it's a part of your very soluble DNA, but from an origin-of-life perspective, that's a hassle. Envisioning a primordial-soup scenario with guanine is tricky, because of this low…
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Hi Orac,
terrasig suggested…
fyi, the title and caption are different. I think the title should be 'triethylene ...'