Yesterday, I discussed a laxative drug that works by drawing water into the intestines (and introduced you to a helpful chart to aid description of particularly ineffable bowel movements).
Here is a drug that works on the same principle, but indirectly - it induces your intestines to secrete ions, which, in turn, cause water to transfer to your intestines and induce bowel movements.
The drug is a prostaglandin - you may know these from drugs that inhibit the formation of certain prostaglandins, such as ibuprofen. As you can see, the class of hormones has a broad range of physiological effects.
- Log in to post comments
More like this
There is a new paper in the Journal of Immunology I found more than a little disconcerting. University of Rochester scientists have found that the cells in the immune system responsible for antibody production, the B-cells, also express high levels of the enzyme cyclooxygenase-2 (Cox-2).…
My apologies to those regular readers who may have noticed my recent case of blogger's malaise. A combination of family sicknesses and having to write a fair bit for the day job seems to have interfered with this week's blogging.
So, what to do? Link to other worthy blogs!
This gives me an…
The penultimate installment of lecture notes in the BIO101 series. Help me make it better - point out errors of fact and suggest improvements:
It is impossible to cover all organ systems in detail over the course of just two lectures. Thus, we will stick only to the basics. Still, I want to…
It is impossible to cover all organ systems in detail over the course of just two lectures. Thus, we will stick only to the basics. Still, I want to emphasize how much organ systems work together, in concert, to maintain the homeostasis (and rheostasis) of the body. I'd also like to emphasize…
any derivatization procedure or without derivatization procedure either in negative or positive mode with ESI OR APCIfor the molecule of 15- HYDROXY LUBIPROSTONE in human plasma upto 1 pg level via LCMSMS or any information to achieve sensitivity.
wow !!
Cool...this is new to me. I love some novel structures. I'm going to have to look up what endogenous prostaglandins look like...
That is a fetching molecule. Any chance of seeing a cyclooxygenase next?
Of course, for another synthetic prostaglandin E1, misoprostil, the bowel movement producing action is called a side-effect. I guess it all depends on the marketing.
any HPLC methods for analisys?
any derivatization procedures for this molecule metabolite 15-hydroxy lubiprostone to detect in human plasma