Loratadine is an antihistamine used for treatment of allergies. Its main distinguishing characteristic is that it is nonsedating, because the molecule minimally penetrates the barrier separating the brain from the bloodstream.
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Another drug that can claim diphenhydramine as an ancestor is fexofenadine, sold as Allegra:
Diphenhydramine for comparison:
Fexofenadine is a member of a later generation of antihistamines. Diphenhydramine worked fine as an antihistamine (still does - you can still get the stuff OTC as Benadryl…
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<3 Loratadine, although Zyrtek has a cuter name and therefore a speedier placebo effect.