- According to new physical activity report card: Only 1 in 8 Canadian kids get enough exercise: http://bit.ly/9Mm5Mu
- Although vitamin E supplementation may be helpful in reducing fatty liver (New England Journal of Medicine), it is at 2x the dose that has previously been found to increase risk of death (Annals of Internal Medicine)
- Yoni takes on the health claims of Danon's Activia and DanActive products (Weighty Matters)
- Men consider excess weight less of a problem than women (Dr. Sharma's Obesity Notes)
- A wonderful discussion about eggs - history, propaganda, and all! (Nutritional Blogma)
- Unless you've been fasting, sports drinks are useless if exercising for up to 1 hour (Sweat Science)
- Chocolate Toddler Formula? Really? (Food Politics)
Have a wonderful weekend - now that the PhD is behind me, I will certainly enjoy mine:)
Congratulations on completing your PhD, Dr. Janiszewki!
The Vitamin E study for NASH is interesting - and while the authors say the study was not designed to evaluate the relative efficacy of Vitamin E and Actos, the former did tend to perform better or equally on many of the outcomes, except insulin resistance and development of diabetes. It might be a cost-effective option for a disease that's becoming increasingly prevalent.
But the higher mortality seen in earlier trials is concerning, although it should be pointed out that most of those trials were done in different patient populations. There does seem to be an increased risk of hemorrhagic stroke, going by the findings of the Physician's Health Study - but again, this was a fairly diverse patient population.
I don't necessarily agree that 800IU is "2x the dose that has previously been found to increase risk of death". The meta-analysis makes it clear that the dose at which the relative risk ratio goes above 1.0 is uncertain. It could be 400IU, or it could even be higher due to the heterogeneity between trials.