Guys win Nobel Prize for making it possible for mice to glow in the dark

The Nobel Prize in Medicine has gone to Mario R. Capecchi, Oliver Smithies, and Sir Martin J. Evans for inventing a technique called Gene Targeting.

According to the NYTimes:

The three scientists were honored for a technique called gene targeting, which lets scientists inactivate or modify particular genes in mice. That in turn lets them study how those genes affect health and disease.

To use this technique, researchers introduce a genetic change into mouse embryonic stem cells. These cells are then injected into mouse embryos. The mice born from these embryos are bred with others, to produce offspring with altered genes.

The first mice with genes manipulated in this way were announced in 1989. More than 10,000 different genes in mice have been studied with the technique, the Nobel committee said. That's about half the genes the rodents have.

''Gene targeting has pervaded all fields of biomedicine. Its impact on the understanding of gene function and its benefits to mankind will continue to increase over many years to come,'' said the citation for the $1.54 million prize.

So what may you ask are the real uses for gene targeting?! Yes! Making crazy freakin' animals that do stuff like glow in the dark and fly!


Ohh yeah.. this technique will lead to millions of lives being saved... but come on - glow in the dark mice! that has to be why they created this great technique, fully deserving of a Nobel Prize.

Ok... maybe there aren't flying mice yet.

More like this

The winners of the 2007 Nobel Prize in Physiology or Medicine were announced this morning. The prize went to Mario R. Capecchi (University of Utah), Martin J. Evans (Cardiff University), and Oliver Smithies (UNC), all for their work contributing to knockout (and knock-in) mice becoming one of the…
No IgNobels here, the 2007 Nobel Prize for Physiology or Medicine has been awarded to Mario R. Capecchi, Martin J. Evans, and Oliver Smithies for a technique that is so incredibly important to modern biomedical research that it's a wonder they didn't get the prize before: This year's Nobel…
This morning, Drs Mario R. Capecchi, Martin J. Evans, and Oliver Smithies were jointly awarded the Nobel Prize in Physiology or Medicine for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells." The technology for homologous…
I somehow managed to lose track of time for a bit, and forgot that it was Nobel season until I saw this morning's announcement that the 2007 Nobel Prize in Medicine hase just been announced, going to Mario R. Capecchi, Sir Martin J. Evans, and Oliver Smithies, for their discoveries of principles…

Flying mice, quite easy.
Take a geneticist, not any geneticist, one loving baseball, give him some mice (use anesthesia) and there your are. Geneticist modified mice locomotion.
Some variants, counter selected, used golf playing molecular biologists. That was a mess.

you guys are sick

By Barbara e Reinard (not verified) on 31 Jan 2008 #permalink

Where can I buy one?

look @ it this way... using this technique, it wiil be easier to enhance/treat human babies from diseas[AKA designer babies]

genitics is a very interesting field in sciece, and one day what we're doing to mice... we could do this to other humans

[sure itd be wired 4 a person to fly in the dark... but how about super smart people or people that can play bettter than mozart & behtoven & bach combined.. wouldnt u want ur kid to be a geniuos? just something 2 think about]

By xXJazzyXx (not verified) on 07 Feb 2008 #permalink

why do that to mice? why not save the planet?

what about a mouse that can save the planet?