cancer
dr. dolittle | March 27, 2014I just read a really neat study from researchers at Texas A&M University. While admittedly this is not comparative physiology, it was just too interesting not to share.
In a study published in the Journal of Nutritional Biochemistry, Dr. Luis Cisneros-Zevallos and colleagues found that administering peach extract to mice inhibited the metastasis (i.e. spread) of breast cancer to other organs, namely the lungs. They attribute this effect to the mix of phenolic compounds in the extract. The dose administered to the mice is equivalent to consuming 2-3 peaches for a human.
In prior work, Dr…
oracknows | March 27, 2014Note: I was busy doing something last night that left me no time to compose any fresh Insolence, which will become apparent by this weekend. In the meantime, however, I'm betting quite a few of you haven't seen this before, and those who have might want to discuss it further in a different environment.
Quackademic medicine.
I love that term, because it succinctly describes the infiltration of pseudoscientific medicine into medical academia. As I've said many times, I wish I had been the one to coin the phrase, but I wasn't. To the best of my ability to determine, I first picked it up from Dr…
oracknows | March 24, 2014After the last couple of days of depressing posts about the utter failure of the FDA to do its job protecting cancer patients from the likes of Stanislaw burzynski, it's time to move on. Given how utterly demoralizing it was to see the FDA, in essence, pass the buck when it comes to protecting cancer patients, I thought back to more amusing times. Oddly enough, some of these times involved Burzynski. Specifically, they involved Burzynski's propagandist Eric Merola, whose spittle-flecked rants never fail to amuse.
For example, a frequent charge made by Burzynski fans like Merola is that we "…
oracknows | March 23, 2014As I sat down to write this bit of Insolence, I had at least two ideas for what I thought would be informative, entertaining, and timely posts. I also didn't want to have to write about Stanislaw Burzynski again after having just done so on Friday, having to note that the FDA caved, granting compassionate use exemptions to use antineoplastons (ANPs) to several patients who had been lobbying for just such exemptions. I already described why what the FDA did was horrifically cynical. When I first saw the message rejoicing of the FDA's decision in message on the Prayers for Elisha Facebook page…
oracknows | March 21, 2014
"Just when I thought I was out, they pull me back in."
I know I've used that quote before several times over the 9+ years that I've been blogging. These days, I probably use it most frequently when it comes to the topic of Stanislaw Burzynski. Every time I think that I can give the topic a rest for a while (and, believe me, I do want to give it a rest), something invariably seems to happen to pull me back in. So it was yesterday when i was made aware of a new development so disappointing that I'm still wiping the dirt off my chin from my jaw dropping to the floor. Even more amazing is that…
oracknows | March 17, 2014A couple of days ago, I got so carried away writing a response in the comments about David Lauser, Sammy Hagar's drummer and husband of a woman named Liza Cozad, who is being used as a tool to pressure the FDA to allow more single patient INDs (also sometimes called compassionate use exemptions) for Stanislaw Burzynski's antineoplastons (ANPs). Sadly, despite decades of failures and recent efforts to expose those failures, I still see credulous stories about Burzynski like this one, in which the reporter completely misses the point.
That's why, in these days when credulous reporters still, in…
cmonforton | March 17, 2014This week will mark the next big step in efforts to institute a federal regulation to protect workers who are exposed to respirable crystalline silica. Tuesday, March 18 will be the first of 14 days of testimony and debate about a proposed silica rule which was released in September 2013 by the Occupational Safety and Health Administration’s (OSHA). The “deadly dust” is associated with malignant and non-malignant respiratory diseases and other adverse health conditions. The hazard has been recognized for centuries, but the U.S. does not have a comprehensive rule on the books to protect the…
dr. dolittle | March 16, 2014 Figure 1 showing RAGE (aka: Ager) expression only in mammals from Sessa et al., PLOS ONE. 9(1): e86903, 2014.
RAGE stands for "receptor for advanced glycation end-products", also known as "AGER", and new research shows that it first appeared in mammals (Sessa et al., 2014). Despite the name, the receptor also binds other signaling molecules such as HMGB1, S100 proteins, beta-amyloid, phosphatidylserine, among others (Xie et al., 2013). RAGE is reportedly involved in diabetes, cardiovascular disease, atherosclerosis, osteoarthritis, cancer, Alzheimer's disease, as well as liver and renal…
oracknows | March 15, 2014Amidst all the sturm und drang after a recent post, I was reminded elsewhere on the blog why I do what I do. So I'm going to do more of it today.
You might recall Liza Cozad, wife of David Lauser, who is the drummer in Sammy Hagar's band. She has an inoperable brain tumor and wants to try Stanislaw Burzynski's antineoplastons. However, because of the partial clinical hold on his clinical trials, she can't get them. Unfortunately, now she and her husband have been using their names to lobby Congress to pressure the FDA to allow an exemption. I wrote a post about this around a month ago. The…
oracknows | March 12, 2014I realize that some of my readers will chide me for saying this, but I usually expect better of Reason. Although I sometimes have a tendency to be a bit—shall we say?—Insolent about libertarians when they pass from a reasonable defense of civil liberties into an Ayn Rand-inspired fantasy world in which the market cures all, useless people keep the supermen (and women) down, and the government is virtually unnecessary, I've usually considered Reason.com to represent a fairly—if you'll excuse the word—reasonable variety of libertarianism. For instance, Ronald Bailey actually once presented…
oracknows | March 10, 2014I forgot if I ever mentioned that I have an article out in the current episode of Skeptical Inquirer about Stanislaw Burzynski. I call it a "primer for skeptics," because that's what it is. So, if you subscribe to SI (Skeptical Inquirer, not Sports Illustrated), read. If not, get thee to a newsstand before it's gone. Thus endeth the plug and beginneth the Insolence.
When last I discussed Stanislaw Burzynski, I noted that, among other things, the state of Texas appears far more interested in putting abortion providers out of business than it does in protecting its citizens suffering from…
oracknows | March 6, 2014One of my favorite shows right now is True Detective, an HBO show in which two cops pursue a serial killer over the course of over 16 years. Starring Woody Harrelson and Matthew McConaughey, it's an amazingly creepy show, and McConaughey is amazing at playing his character, Rustin Cohle. I'm sad that the show will be ending this week.
Unfortunately, as much as I like Matthew McConaughey as an actor, he is in part responsible for re-inspiring a movement that has the potential to do profound harm to patients and cancer research. That's because his other big role over the last year has been in…
egrossman | March 3, 2014“For us it’s personal,” said Jeannie Economos, Farmworker Association of Florida Pesticide Safety and Environmental Health Project Coordinator. “It’s a daily issue for us. Every day with a weaker protection standard is another day a worker is exposed to pesticides,” she said.
On February 20th , the US Environmental Protection Agency (EPA) announced proposed revisions to its Worker Protection Standard for agricultural pesticides, the first since the existing standard was established in 1992 – and the second proposed update to the standard since its introduction in 1974. EPA has called the…
sa smith | February 24, 2014WHY IS THIS NOT STANDARD THERAPY YET?
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
I wrote about this last year:
‘Dismal prognosis’ with leukemia? Nothing a GMO virus cant fix.
In the previous study, scientists took cytotoxic T-cells from five B-ALL patients, and infected them with a genetically modified virus. This GMO virus had a genome that essentially contained a 'cheat sheet' for teaching those CTLs how to kill B-ALL cancer cells. Four out of the five B-ALL patients recovered enough that they could get a bone marrow transplant.
In…
oracknows | February 19, 2014Remember our old buddy Eric Merola? He's the guy who made two—count 'em—two crappy, conspiracy-laden, misinformation-ridden, astonishingly bad bits of "great man" propaganda disguised as documentaries about a Houston cancer doctor peddling unproven cancer treatments and charging his patients tens and even hundreds of thousands of dollars for the privilege of being under his care while receiving this magic elixir, known as antineoplastons. Believe it or not, this post is not going to be about Stanislaw Burzynski, although it will be about Eric Merola's latest project.
Over the last several…
oracknows | February 16, 2014The last couple of weeks, I've made allusions to the "Bat Signal" (or, as I called it, the "Cancer Signal," although that's a horrible name and I need to think of a better one). Basically, when Bat Cancer Signal goes up (hey, I like that one better, but do bats get cancer?), it means that a study or story has hit the press that demands my attention. It happened again just last week, when stories started hitting the press hot and heavy about a new study of mammography, stories with titles like Vast Study Casts Doubts on Value of Mammograms and Do Mammograms Save Lives? ‘Hardly,’ a New Study…
oracknows | February 15, 2014Regular readers know my frustration with the Texas Medical Board. Why is it, I've often wondered, that Stanislaw Burzynski can keep peddling his unproven cancer treatment with seeming impunity for nearly four decades, with every attempt of the TMB over the last four decades seemingly being utterly ineffective? It's not as though Burzynski is alone. There are many other doctors who should, in the opinion of many, have their licenses revoked but keep practicing in Texas. Even when there's a doctor who is clearly an immediate threat to patients, it's hard to get the TMB to do anything. Ditto…
cmonforton | February 13, 2014The American Cancer Society (ACS) and the American Medical Association (AMA) have offered their endorsement to the Occupational Safety and Health Administration’s (OSHA) regulatory efforts to reduce workers’ exposure to respirable silica. It’s a hazard that can cause the disabling lung disease silicosis, as well as lung cancer and other disorders. The ACS’s and AMA’s official statements of support are found in the agency's rulemaking for its proposed silica rule. The docket closed on Tuesday for this phase of the rulemaking process.
The AMA’s support comes in the form of a policy statement…
oracknows | February 12, 2014The other day, I got to thinking about cults. The reason is that it's been clear to me for some time that the antivaccine movement is a quack cult. In fact, a lot of quack groups are very cultish, the example that reminded me of this having been an excellent report published by a young mother named Megan Sandlin, who used to be antivaccine but is no longer. Her post, Leaving the Antivaccine Movement, reminded me very much of the genre of "deconversion" stories, in which atheists who were once fundamentalist Christians describe the process of their losing their religion or cult members…
oracknows | February 11, 2014I don't know if it's a sign that I've arrived as being a bit more influential than just a blogger or just dumb luck when reporters start sending me things, but I'll take it. It's like blog fodder being served to me on the proverbial silver platter. Unfortunately, as a result of receiving a press release, FDA Denies Treatment to Two Terminally Ill Young Women, from two different sources, after yesterday's hilarious (if I do say so myself) bit of fun with a certain woman who fancies herself a "Thinker" when everything she writes shows that she is anything but, I find myself tackling a much more…